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Federal
Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers
U.S. Department of Health & Human Services —
Background Previously, we have demonstrated a marked inhibition of codeine glucuronidation by diclofenac in human liver tissue homogenate. We therefore aimed to... -
Federal
Influence of twenty-five per cent human serum albumin on total and ionized calcium concentrations
U.S. Department of Health & Human Services —
Background: A inverse correlation has been found between changes in ionized calcium concentrations and the addition of albumin in vitro, which may explain adverse... -
Federal
Receptorphin: A conserved peptide derived from the sequence of the opioid receptor, with opioid displacement activity and potent antiproliferative actions in tumor cells
U.S. Department of Health & Human Services —
Background In addition to endogenous opioids, a number of peptide sequences, derived from endogenous (hemorphins, alphaS1-casomorphin), and exogenous proteins... -
Federal
A successful pregnancy following SEM fine tuning of hormonal priming
U.S. Department of Health & Human Services —
Background Manipulation of the uterine epithelium utilising standard dose exogenous oestrogen (E2) and progesterone (P4) has been shown to achieve a mature secretory... -
Federal
Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40)
U.S. Department of Health & Human Services —
Background SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been... -
Federal
Hypothermia and neurologic outcome in patients following cardiac arrest: should we be hot to cool off our patients?
U.S. Department of Health & Human Services —
Hypothermia as a protectant of neurologic function in the treatment of cardiac arrest patients, although not a new concept, is now supported by two recent randomized,... -
Federal
A new device for 100 per cent humidification of inspired air
U.S. Department of Health & Human Services —
A new humidifier for use during mechanical ventilation in endotracheally intubated patients is described and tested. The humidifier is based on a heat-moisture... -
Federal
The methionine salvage pathway in
U.S. Department of Health & Human Services —
Background Polyamine synthesis produces methylthioadenosine, which has to be disposed of. The cell recycles it into methionine through methylthioribose (MTR). Very... -
Federal
Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses
U.S. Department of Health & Human Services —
Background This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the... -
Federal
Experience collecting interim data on mortality: an example from the RALES study
U.S. Department of Health & Human Services —
Introduction The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary... -
Federal
Chromosomal mapping, gene structure and characterization of the human and murine
U.S. Department of Health & Human Services —
Background Rab GTPases are regulators of intracellular membrane traffic. The Rab27 subfamily consists of Rab27a and Rab27b. Rab27a has been recently implicated in... -
Federal
Prehospital point of care testing of blood gases and electrolytes — an evaluation of IRMA
U.S. Department of Health & Human Services —
Background: This study evaluated the feasibility of blood gas analysis and electrolyte measurements during emergency transport prior to hospital admission. Results: A... -
Federal
The estimated economic burden of genital herpes in the United States. An analysis using two costing approaches
U.S. Department of Health & Human Services —
Background Only limited data exist on the costs of genital herpes (GH) in the USA. We estimated the economic burden of GH in the USA using two different costing... -
Federal
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
U.S. Department of Health & Human Services —
Background HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing... -
Federal
Response to Fionula Brennan's Commentary "A follow-up to 'Anti-cytokine therapy in chronic destructive arthritis' by Wim B van den Berg"
U.S. Department of Health & Human Services —
Response to Fionula Brennan's Commentary "A follow-up to 'Anti-cytokine therapy in chronic destructive arthritis' by Wim B van den Berg" -
Federal
Cytosolic acidification as a signal mediating hyperosmotic stress responses in
U.S. Department of Health & Human Services —
Background Dictyostelium cells exhibit an unusual response to hyperosmolarity that is distinct from the response in other organisms investigated: instead of... -
Federal
No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months
U.S. Department of Health & Human Services —
Objective To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia. Method We randomized 389 patients... -
Federal
The regulation of CD5 expression in murine T cells
U.S. Department of Health & Human Services —
Background CD5 is a pan-T cell surface marker that is also present on a subset of B cells, B-1a cells.Functional and developmental subsets of T cells express... -
Federal
Genetic transformation of
U.S. Department of Health & Human Services —
Background Efficient transformation and regeneration methods are a priority for successful application of genetic engineering to vegetative propagated plants such as... -
Federal
Utility of postintubation chest radiographs in the intensive care unit
U.S. Department of Health & Human Services —
Objective: To determine the clinical usefulness of immediate (stat) chest radiographs after endotracheal intubation when performed by experienced critical care...