288 datasets found
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Federal
Transcriptional analysis of lung from mice flown on the RR-6 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-6 (RR-6) study was to evaluate muscle atrophy in mice during spaceflight and to test the efficacy of a novel therapeutic to... -
Federal
Effects of microgravity on human iPSC-derived neural organoids on the International Space Station - cortical organoids
National Aeronautics and Space Administration —
Research conducted on the International Space Station (ISS) in low-Earth orbit (LEO) has shown the effects of microgravity on multiple organs. To investigate the... -
Federal
Rodent Research-1 (RR1) NASA Validation Flight: Mouse extensor digitorum longus muscle transcriptomic and epigenomic data
National Aeronautics and Space Administration —
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited... -
Federal
RR-1 and RR-3 mouse liver transcriptomics with and without ERCC control RNA spike-ins
National Aeronautics and Space Administration —
Proper interpretation of RNA sequencing data requires an understanding of assay sensitivity and sources of variability. To this end, the External RNA Control... -
Federal
Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations - Proteomics data
National Aeronautics and Space Administration —
The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was... -
Federal
Microbiome profiling of feces from mice flown on the RR-10 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-10 Mission (RR-10) was to investigate how spaceflight affects the cellular and molecular mechanisms of normal bone tissue... -
Federal
Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system
National Aeronautics and Space Administration —
The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular... -
Federal
Utilizing the KSC Fixation Tube to Conduct Human-Tended Plant Biology Experiments on a Suborbital Spaceflight
National Aeronautics and Space Administration —
Suborbital spaceflights now enable human-tended research investigating short-term gravitational effects in biological systems, eliminating the need for complex... -
Federal
BRIC-23 GeneLab Process Verification Test: Bacillus subtilis transcriptomic, proteomic, and metabolomic data
National Aeronautics and Space Administration —
Microbes interact with humans in complex ways and understanding how they respond to the spaceflight environment is important to the success of future manned... -
Federal
Influence of Sex Hormones on Nervous System and Musculoskeletal Health in Micro and Martian Fractional Gravity in Rat Analogues (Force Plate; Soleus)
National Aeronautics and Space Administration —
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle... -
Federal
Effects of spaceflight on murine skeletal muscle gene expression
National Aeronautics and Space Administration —
Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and shifts towards faster muscle fiber types. To identify changes in gene... -
Federal
Transcriptional profiling of tibialis anterior muscle from mice flown on the RR-23 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-23 mission (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function of... -
Federal
Lower eukaryotic isolates belonging to class Tremellomycetes isolated from International Space Station Genome sequencing and assembly
National Aeronautics and Space Administration —
Genome sequencing and assembly of lower Eukaryotic isolates belonging to class Tremellomycetes isolated from International Space Station -
Federal
Transcriptional analysis of dorsal skin from mice flown on the RR-6 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-6 (RR-6) study was to evaluate muscle atrophy in mice during spaceflight and to test the efficacy of a novel therapeutic to... -
Federal
Transcriptional and proteomic response of Pseudomonas aeruginosa PAO1 to spaceflight conditions involves Hfq regulation and reveals a role for oxygen
National Aeronautics and Space Administration —
This study describes the transcriptional response of P. aeruginosa PAO1 to low-Earth orbit environmental conditions. Our aim was to assess whether the microgravity... -
Federal
The response of murine cartilages to 30 days of microgravity
National Aeronautics and Space Administration —
Articular and sterno-costal cartilages were isolated from skeletally-mature mice flown for 30 days on the BION-M1 mission. Samples were characterized histologically... -
Federal
Microbial Observatory (ISS-MO): Molecular characterization of Bacillus issensis, sp. nov., isolated from various quarters of the International Space Station
National Aeronautics and Space Administration —
As part of an ongoing effort to catalogue microbial communities inhabiting the International Space Station (ISS) crew-associated environmental samples were collected... -
Federal
Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station (ISS)
National Aeronautics and Space Administration —
On Earth, people spend 90% of their time indoors where dust and moisture can facilitate rapid microbial growth, especially fungi. The International Space Station is a... -
Federal
Reproducible changes in gut microbiome reveal a shift in microbial and host metabolism during spaceflight
National Aeronautics and Space Administration —
Data were generated as part of a NASA-funded study (Turek F (PI) et al. Effects of Spaceflight on Gastrointestinal Microbiota in Mice: Mechanisms and Impact on Multi-...
288 datasets found