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Federal
Proton irradiation augments the reduction in tumor progression observed with advanced age
National Aeronautics and Space Administration —
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have... -
Federal
Mouse femur LC-MSMS upon weightlessness
National Aeronautics and Space Administration —
Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronaut xe2 x80 x99s health and safety. However consequences on B... -
Federal
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
National Aeronautics and Space Administration —
Given the limited knowledge of the biological impact of spaceflight, a multi-omics, systems biology approach was used to investigate NASA’s GeneLab data and astronaut... -
Federal
Fault Tolerance, Diagnostics, and Prognostics in Aircraft Flight
National Aeronautics and Space Administration —
Abstract In modern fighter aircraft with statically unstable airframe designs, the flight control system is considered flight critical, i.e. the aircraft will... -
Federal
Microarray Analysis of Space-flown Murine Thymus Tissue
National Aeronautics and Space Administration —
Microarray Analysis of Space-flown Murine Thymus Tissue Reveals Changes in Gene Expression Regulating Stress and Glucocorticoid Receptors. We used microarrays to... -
Federal
Microarray Analysis of Space-flown Murine Thymus Tissue
National Aeronautics and Space Administration —
Microarray Analysis of Space-flown Murine Thymus Tissue Reveals Changes in Gene Expression Regulating Stress and Glucocorticoid Receptors. We used microarrays to... -
Federal
Transcription profiling of activated human T cells induced by microgravity to identify apoptotic genes and other immune response genes
National Aeronautics and Space Administration —
The purpose of this study was to search for microgravity-sensitive genes specifically for apoptotic genes influenced by the microgravity environment and other genes... -
Federal
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
National Aeronautics and Space Administration —
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We... -
Federal
['Inflammatory gene expression signatures in idiopathic intracranial hypertension: possible implications in microgravity-induced ICP elevation - CSF']
National Aeronautics and Space Administration —
['The visual impairment and intracranial pressure (VIIP) syndrome is a neuro-ophthalmologic condition described in astronauts returning from long duration space... -
Federal
NARSTO EPA Supersite (SS) Baltimore, Semicontinuous Elements in Aerosol Sampler (SEAS) Particulate Matter (PM) 25 Metal Cytokines Data
National Aeronautics and Space Administration —
NARSTO_EPA_SS_BALTIMORE_SEAS_PM25_METAL_CYTOKINES is the North American Research Strategy for Tropospheric Ozone (NARSTO) Environmental Protection Agency (EPA)... -
Federal
Gene expression profiling for spaceflight induced-neuroinflammation in the mouse brain
National Aeronautics and Space Administration —
The health risk from spaceflight-induced neuronal damage and potential adverse neurovascular effects is a chief concern. More recently, it has been proposed that... -
Federal
Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice (echocardiogram/ultrasonography)
National Aeronautics and Space Administration —
Purpose: Astronauts traveling beyond low Earth orbit will be exposed to high linear energy transfer charged particles. Because there is concern about the adverse... -
Federal
Effect of microgravity on brain gene expression in mice
National Aeronautics and Space Administration —
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of... -
Federal
Effects of low dose space radiation exposures on the splenic metabolome
National Aeronautics and Space Administration —
Future space missions will include return to the Moon and long duration deep space roundtrip missions to Mars. Leaving the protection that Low Earth Orbit provides... -
Federal
Gene expression in human peripheral blood 48 hours after exposure to ionizing radiation
National Aeronautics and Space Administration —
Analysis of human peripheral blood 48 hours after irradiation ex vivo with graded doses of gamma rays. Results have been used in building and testing classifiers to... -
Federal
Gene expression data from 4T1 irradiated tumors treated with TGFbeta blockade
National Aeronautics and Space Administration —
Accumulating data support the concept that ionizing radiation therapy (RT) has the potential to convert the tumor into an in situ individualized vaccine; however this... -
Federal
['RNA sequencing of zebrafish embryos under simulated microgravity conditions']
National Aeronautics and Space Administration —
['To reveal the potential mechanisms involved in the dysfunction of antiviral immune responses under simulated microgravity conditions, we investigated the... -
Federal
Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
National Aeronautics and Space Administration —
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent... -
Federal
Gene expression profiling of human peripheral blood lymphocytes cultured in modeled microgravity
National Aeronautics and Space Administration —
In the present study we analyzed miRNA and mRNA expression profiles in human peripheral blood lymphocytes (PBLs) incubated in microgravity condition simulated by a... -
Federal
Transcription profiling of activated human T cells induced by microgravity to identify apoptotic genes and other immune response genes
National Aeronautics and Space Administration —
The purpose of this study was to search for microgravity-sensitive genes specifically for apoptotic genes influenced by the microgravity environment and other genes...