288 datasets found
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Federal
Transcriptional profiling of gastrocnemius muscle from rats flown on the SLS-1 mission
National Aeronautics and Space Administration —
The Spacelab Life Sciences (SLS) program was a series of payloads that used the facilities of an entire Spacelab module to conduct a variety of life science... -
Federal
SpaceX Inspiration4 Oral, Nasal, and Skin Metagenomic and Metatranscriptomic Microbial Swabs
National Aeronautics and Space Administration —
The SpaceX Inspiration4 mission was a 3-day mission with four private astronauts to low Earth orbit that occurred in September 2021. The crew collected biospecimen... -
Federal
Transcriptional profiling of the right gastrocnemius muscle from mice flown on the RR-1 mission
National Aeronautics and Space Administration —
In the NASA Rodent Research-1 (RR-1) validation study, ten 16-week-old female C57BL/6J mice were flown to the ISS for 37 days before euthanasia and subsequent... -
Federal
Transcriptional profiling of spleens from mice flown on the RR-9 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-9 (RR-9) mission was to use mice to understand the molecular basis of phenomena that affect astronauts during long-duration... -
Federal
Spatial characterization of microbial communities on multi-species leafy greens grown simultaneously in the Veggie vegetable production systems on the International Space Station VEG-03F
National Aeronautics and Space Administration —
Investigates the microbial communities of plants and Veggie pillow components with culturable and non-culturable methods providing qualitative and quantitative data.... -
Federal
Altered rodent gait characteristics after ~35 days in orbit aboard the International Space Station
National Aeronautics and Space Administration —
The long-term adaptations to microgravity and other spaceflight challenges within the confines of a spacecraft, and readaptations to weight-bearing upon reaching a... -
Federal
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster (Immunohistochemistry)
National Aeronautics and Space Administration —
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in... -
Federal
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster
National Aeronautics and Space Administration —
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in... -
Federal
Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight
National Aeronautics and Space Administration —
The Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the spaceflight-altered cytosine... -
Federal
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats (Femur - microCT, three-point bending, histomorphometry)
National Aeronautics and Space Administration —
Reduced skeletal loading leads to marked bone loss. Animal models of hindlimb suspension are widely used to assess alterations in skeleton during the course of... -
Federal
Effect of spaceflight on liver from mice flown on the ISS for 33 days: transcriptional analysis
National Aeronautics and Space Administration —
The objective of the Rodent Research-9 (RR-9) mission was to use mice to understand the molecular basis of phenomena that affect astronauts during long-duration... -
Federal
Transcription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1
National Aeronautics and Space Administration —
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to a tumor promoter during neoplastic... -
Federal
RR-1 and RR-3 mouse liver transcriptomics with and without ERCC control RNA spike-ins
National Aeronautics and Space Administration —
Proper interpretation of RNA sequencing data requires an understanding of assay sensitivity and sources of variability. To this end, the External RNA Control... -
Federal
Head-Down Tilt As a Model for Intracranial and Intraocular Pressures, and Retinal Changes during Spaceflight (Eye, MRI, Optical Coherence Tomography, Tonometry, A-scan)
National Aeronautics and Space Administration —
This ground-based program was intended to address the etiology of visual system structural and functional changes observed in astronauts during both inflight and... -
Federal
Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station
National Aeronautics and Space Administration —
The on-going Microbial Observatory Experiments on the International Space Station (ISS) revealed the presence of various microorganisms that may be affected by the... -
Federal
Transcriptomic Effects on the Mouse Heart Following 30 Days on the International Space Station.
National Aeronautics and Space Administration —
Efforts to understand the impact of spaceflight on the human body stem from growing interest in long-term space travel. Multiple organ systems are affected by... -
Federal
Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target (Tibialis Anterior, RR9, Western Blot)
National Aeronautics and Space Administration —
We examined the effects of ~30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone... -
Federal
Characterizing Epigenetic Changes in Methylation Mutants (elp2-5 and met1-7) in Response to Spaceflight. [Bisulfite-Seq]
National Aeronautics and Space Administration —
Epigenetic changes in the DNA methylome are increasingly shown to play an integral role in regulating gene expression necessary for plants’ adaption to environmental... -
Federal
Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina
National Aeronautics and Space Administration —
The purpose of this study was to determine whether the spaceflight environment induces oxidative damage on ocular structure and how gene expression profiles change... -
Federal
Draft Genomes of Fungi Isolated from the International Space Station during the Microbial Tracking-2 Experiment
National Aeronautics and Space Administration —
Draft genomes of fungi isolated from different surfaces on the International Space Station, as part of the Microbial Tracking 2 mission (ISS-MOP).
288 datasets found