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Federal
Chromosomal mapping, gene structure and characterization of the human and murine
U.S. Department of Health & Human Services —
Background Rab GTPases are regulators of intracellular membrane traffic. The Rab27 subfamily consists of Rab27a and Rab27b. Rab27a has been recently implicated in... -
Federal
Genetics of rheumatoid arthritis: confronting complexity
U.S. Department of Health & Human Services —
The genetic basis for rheumatoid arthritis (RA) is likely to be extremely complex. Even the role of MHC genes remains to be fully defined, and may involve interactive... -
Federal
Appetite suppressants and valvular heart disease – a systematic review
U.S. Department of Health & Human Services —
Background Although appetite suppressants have been implicated in the development of valvular heart disease, the exact level of risk is still uncertain. Initial... -
Federal
MICE, a program to track and monitor animals in animal facilities
U.S. Department of Health & Human Services —
Background A growing number of laboratories are using the mouse as a model system in developmental biology as well as in molecular biology. Surprisingly, most of... -
Federal
Case-oriented computer-based-training in radiology: concept, implementation and evaluation
U.S. Department of Health & Human Services —
Background Providing high-quality clinical cases is important for teaching radiology. We developed, implemented and evaluated a program for a university hospital to... -
Federal
Policy mapping for establishing a national emergency health policy for Nigeria
U.S. Department of Health & Human Services —
Background The number of potential life years lost due to accidents and injuries though poorly studied has resulted in tremendous economic and social loss to Nigeria.... -
Federal
Debate: A subversive view of subsets - a dissident clinician's opinion
U.S. Department of Health & Human Services —
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients... -
Federal
Ligamentous rupture of the ACL associated with dislocated fracture of the proximal tibial physis in a 12-year-old boy
U.S. Department of Health & Human Services —
Background Dislocated fracture of the proximal physeal plate of the tibia with or without metaphyseal fragment is rare in children. This unusual fracture classically... -
Federal
Quantitative analysis of DNA levels in maternal plasma in normal and Down syndrome pregnancies
U.S. Department of Health & Human Services —
Background We investigated fetal and total DNA levels in maternal plasma in patients bearing fetuses affected with Down syndrome in comparison to controls carrying... -
Federal
The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator
U.S. Department of Health & Human Services —
Background Endoplasmic reticulum retention of misfolded cystic fibrosis transmembrane conductance regulator (CFTR) mutants and their rapid degradation is the major... -
Federal
Why the fair innings argument is not persuasive
U.S. Department of Health & Human Services —
The fair innings argument (FIA) is frequently put forward as a justification for denying elderly patients treatment when they are in competition with younger patients... -
Federal
Taking stock of gene therapy for cystic fibrosis
U.S. Department of Health & Human Services —
The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal... -
Federal
Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder
U.S. Department of Health & Human Services —
Idiopathic pulmonary fibrosis is a chronic and usually progressive lung disorder of unknown etiology. A growing body of evidence suggests that, in contrast to other... -
Federal
Retrovirus-delivered siRNA
U.S. Department of Health & Human Services —
The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene... -
Federal
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
U.S. Department of Health & Human Services —
Background HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element... -
Federal
Should all patients receive dual chamber pacing ICDs? The rationale for the DAVID trial
U.S. Department of Health & Human Services —
All of the prospective multicenter trials that support the use of implantable defibrillators have used single chamber pacemakers/implantable cardiovertor... -
Federal
Icodextrin as salvage therapy in peritoneal dialysis patients with refractory fluid overload
U.S. Department of Health & Human Services —
Background Icodextrin is a high molecular weight, starch-derived glucose polymer, which is capable of inducing sustained ultrafiltration over prolonged (12–16 hour)... -
Federal
Editorial: The upper airway - the forgotten organ
U.S. Department of Health & Human Services —
The upper airway is an organ not often investigated. Relatively little is known about its complex functions, and misunderstandings abound. The paper by Thomachot et... -
Federal
A prospective study of rural drinking water quality and acute gastrointestinal illness
U.S. Department of Health & Human Services —
Background This study examined the relationship between the bacteriological contamination of drinking water from private wells and acute gastrointestinal illness... -
Federal
Are women and providers satisfied with antenatal care? Views on a standard and a simplified, evidence-based model of care in four developing countries
U.S. Department of Health & Human Services —
Background This study assessed women and providers' satisfaction with a new evidence-based antenatal care (ANC) model within the WHO randomized trial conducted in...