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Federal
Two C or not two C: recurrent disruption of Zn-ribbons, gene duplication, lineage-specific gene loss, and horizontal gene transfer in evolution of bacterial ribosomal proteins
U.S. Department of Health & Human Services —
Background Ribosomal proteins are encoded in all genomes of cellular life forms and are, generally, well conserved during evolution. In prokaryotes, the genes for... -
Federal
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
U.S. Department of Health & Human Services —
Background HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element... -
Federal
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity
U.S. Department of Health & Human Services —
Background The p53 protein is activated by genotoxic stress, oncogene expression and during senescence, p53 transcriptionally activates genes involved in growth... -
Federal
MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
U.S. Department of Health & Human Services —
Background Three macromolecular assemblages, the lid complex of the proteasome, the COP9-Signalosome (CSN) and the eIF3 complex, all consist of multiple proteins... -
Federal
Central effects of clozapine in regulating micturition in anesthetized rats
U.S. Department of Health & Human Services —
Background We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited... -
Federal
Patent AT-E401743-T1: [Translated] METHOD FOR CODING MOVING IMAGES AND METHOD FOR DECODING MOVING IMAGES
U.S. Department of Health & Human Services —
A moving picture coding apparatus includes a motion estimation unit (101) for performing motion estimation by fixing the one of two reference pictures as a reference... -
Federal
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
U.S. Department of Health & Human Services —
Background HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing... -
Federal
Down-regulation of the alpha-2C adrenergic receptor: involvement of a serine/threonine motif in the third cytoplasmic loop
U.S. Department of Health & Human Services —
Background The mechanisms by which alpha-2 adrenergic receptors are down-regulated following chronic exposure to agonist are not well understood. Interestingly, the... -
Federal
Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family
U.S. Department of Health & Human Services —
CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus.... -
Federal
Mutational analysis of human profilin I reveals a second PI(4,5)-P
U.S. Department of Health & Human Services —
Background Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P2).... -
Federal
Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
U.S. Department of Health & Human Services —
Background Nicotine is a psychoactive drug presenting a diverse array of biological activities, some positive, such as enhancement of cognitive performances, others... -
Federal
Identification of four families of yCCR4- and Mg
U.S. Department of Health & Human Services —
Background The yeast yCCR4 factor belongs to the CCR4-NOT transcriptional regulatory complex, in which it interacts, through its leucine-rich repeat (LRR) motif with... -
Federal
Problems in early diagnosis of bladder cancer in a spinal cord injury patient: Report of a case of simultaneous production of granulocyte colony stimulating factor and parathyroid hormone-related protein by squamous cell carcinoma of urinary bladder
U.S. Department of Health & Human Services —
Background Typical symptoms and signs of a clinical condition may be absent in spinal cord injury (SCI) patients. Case presentation A male with paraplegia was passing... -
Federal
Patent AT-E401390-T1: [Translated] CYTOKINE (ZCYTOR17 LIGAND)
U.S. Department of Health & Human Services —
There is provided an antibody or antibody fragment which specifically binds to a portion of SEQ ID NO:2, wherein said portion consists of between 30 and 100... -
Federal
The PRC-barrel: a widespread, conserved domain shared by photosynthetic reaction center subunits and proteins of RNA metabolism
U.S. Department of Health & Human Services —
The PRC-H β-barrel domain, a distinct cytoplasmic β-barrel domain whose fold has no close structural relationship to any other well known β-barrel domain, is the... -
Federal
Research Article: BMC Immunology
U.S. Department of Health & Human Services —
Background Peroxynitrite is increasingly proposed as a contributor to defence system in marine bivalve. It can be formed by combinaison of superoxide and nitric... -
Federal
Patent AT-E401362-T1: [Translated] METHOD FOR SEPARATING A POLY(ARYLENE ETHER) FROM A SOLVENT
U.S. Department of Health & Human Services —
A method of separating a polymer-solvent mixture is described wherein a polymer-solvent mixture is heated prior to its introduction into an extruder comprising as... -
Federal
Patent AT-E401302-T1: [Translated] NITRIC ACID ESTER DERIVATIVES OF COX-2 INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF INFLAMMATION AND CARDIOVASCULAR DISEASES
U.S. Department of Health & Human Services —
The use of compounds of formula (I), or their salts, for the preparation of medicaments for the treatment of urinary incontinence, is new. A-X1-NO2 (I). A = R(COX)t;... -
Federal
Patent AT-E401519-T1: [Translated] RESIDUAL PRESSURE VALVE
U.S. Department of Health & Human Services —
The residual pressure valve comprises a rubber tube (2) which acts as a valve seat and holds the gas control component (1) under tension. The control component has... -
Federal
Patent AT-E399766-T1: [Translated] AROMATIC HETEROCYCLES CONTAINING NITROGEN
U.S. Department of Health & Human Services —
The present invention concerns a process for preparing a compound represented by the following general formula (a- nor a pharmacologically acceptable salt or hydrate...