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Federal
Diagnostic and treatment characteristics of polycystic ovary syndrome: descriptive measurements of patient perception and awareness from 657 confidential self-reports
U.S. Department of Health & Human Services —
Background This investigation was undertaken to describe patient perception and awareness of the polycystic ovary syndrome (PCOS), the most common cause of... -
Federal
Genetic determinants of mammographic density
U.S. Department of Health & Human Services —
Background Changes in breast density are highly correlated with steroid hormone exposure. Materials and methods In a cross-sectional study of 396 Caucasian and... -
Federal
To keep the catch – that is the question: a personal account of the 3rd Annual EULAR Congress, Stockholm
U.S. Department of Health & Human Services —
The 3rd Annual EULAR Congress, held in Stockholm on 12–15 June 2002, had a turnout of 8300 delegates, almost identical to last year's record attendance level in... -
Federal
Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug
U.S. Department of Health & Human Services —
Background Antibody-directed enzyme prodrug therapy (ADEPT) is a promising new approach to deliver anticancer drugs selectively to tumor cells. In this approach, an... -
Federal
Little qualitative RNA misexpression in sterile male F
U.S. Department of Health & Human Services —
Background Although the genetics of hybrid sterility has been the subject of evolutionary studies for over sixty years, no one has shown the reason(s) why alleles... -
Federal
Clinical review: Splanchnic ischaemia
U.S. Department of Health & Human Services —
Inadequate splanchnic perfusion is associated with increased morbidity and mortality, particularly if liver dysfunction coexists. Heart failure, increased intra-... -
Federal
Articular cartilage and changes in Arthritis: Collagen of articular cartilage
U.S. Department of Health & Human Services —
The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component... -
Federal
Acetaminophen toxicity: suicidal vs accidental
U.S. Department of Health & Human Services —
Introduction Acetaminophen toxicity, which can lead to hepatotoxicity, is a burden on our health care system and contributes significantly to intensive care unit... -
Federal
Effects of microcosm scaling and food resources on growth and survival of larval
U.S. Department of Health & Human Services —
Background We used a simple experimental design to test for the effects of microcosm scaling on the growth and survival of the mosquito, Culex pipiens. Microcosm and... -
Federal
A draft annotation and overview of the human genome
U.S. Department of Health & Human Services —
Background The recent draft assembly of the human genome provides a unified basis for describing genomic structure and function. The draft is sufficiently accurate to... -
Federal
Cytosolic acidification as a signal mediating hyperosmotic stress responses in
U.S. Department of Health & Human Services —
Background Dictyostelium cells exhibit an unusual response to hyperosmolarity that is distinct from the response in other organisms investigated: instead of... -
Federal
Preventing infection from reusable medical equipment: a systematic review
U.S. Department of Health & Human Services —
Background In 2000, the World Health Organization (WHO) had eight sets of conflicting recommendations for decontaminating medical equipment. We conducted a systematic... -
Federal
Pharmacology of airway afferent nerve activity
U.S. Department of Health & Human Services —
Afferent nerves in the airways serve to regulate breathing pattern, cough, and airway autonomic neural tone. Pharmacologic agents that influence afferent nerve... -
Federal
Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model
U.S. Department of Health & Human Services —
Background Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-... -
Federal
Therapy of ankylosing spondylitis and other spondyloarthritides: established medical treatment, anti-TNF-α therapy and other novel approaches
U.S. Department of Health & Human Services —
Therapeutic options for patients with more severe forms of spondyloarthritis (SpA) have been rather limited in recent decades. There is accumulating evidence that... -
Federal
Physician perceptions of primary prevention: qualitative base for the conceptual shaping of a practice intervention tool
U.S. Department of Health & Human Services —
Background A practice intervention must have its basis in an understanding of the physician and practice to secure its benefit and relevancy. We used a formative... -
Federal
Crystal structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18
U.S. Department of Health & Human Services —
Background Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a... -
Federal
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
U.S. Department of Health & Human Services —
Background We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant... -
Federal
Within the fold: assessing differential expression measures and reproducibility in microarray assays
U.S. Department of Health & Human Services —
Fold-change' cutoffs have been widely used in microarray assays to identify genes that are differentially expressed. More accurate measures are required to identify... -
Federal
The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study
U.S. Department of Health & Human Services —
Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this...