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Federal
Delayed union of femoral fractures in older rats:decreased gene expression
U.S. Department of Health & Human Services —
Background Fracture healing slows with age. While 6-week-old rats regain normal bone biomechanics at 4 weeks after fracture, one-year-old rats require more than 26... -
Federal
Aminoglycoside antibiotics and autism: a speculative hypothesis
U.S. Department of Health & Human Services —
Background Recently, it has been suspected that there is a relationship between therapy with some antibiotics and the onset of autism; but even more curious, some... -
Federal
Determinants of abstract acceptance for the Digestive Diseases Week – a cross sectional study
U.S. Department of Health & Human Services —
Background The Digestive Diseases Week (DDW) is the major meeting for presentation of research in gastroenterology. The acceptance of an abstract for presentation at... -
Federal
Penis size: Survey of female perceptions of sexual satisfaction
U.S. Department of Health & Human Services —
Background Does the size of the male penis, in terms of length or width, make a difference in female sexual satisfaction? Method To study the effect of penis width... -
Federal
An international survey of patients with thalassemia major and their views about sustaining life-long desferrioxamine use
U.S. Department of Health & Human Services —
Background Management of thalassemia major requires patients to have life-long access to a treatment regimen of regular blood transfusions coupled with iron chelation... -
Federal
MICE, a program to track and monitor animals in animal facilities
U.S. Department of Health & Human Services —
Background A growing number of laboratories are using the mouse as a model system in developmental biology as well as in molecular biology. Surprisingly, most of... -
Federal
Appetite suppressants and valvular heart disease – a systematic review
U.S. Department of Health & Human Services —
Background Although appetite suppressants have been implicated in the development of valvular heart disease, the exact level of risk is still uncertain. Initial... -
Federal
Application of the development stages of a cluster randomized trial to a framework for evaluating complex health interventions
U.S. Department of Health & Human Services —
Introduction Trials of complex health interventions often pose difficult methodologic challenges. The objective of this paper is to assess the extent to which the... -
Federal
Case-oriented computer-based-training in radiology: concept, implementation and evaluation
U.S. Department of Health & Human Services —
Background Providing high-quality clinical cases is important for teaching radiology. We developed, implemented and evaluated a program for a university hospital to... -
Federal
Endothelial [Ca2+]iis an integrating signal for the vascular tone in rat aortae
U.S. Department of Health & Human Services —
Although various endothelium-dependent relaxing factors (endothelial autacoids) are released upon the elevation of endothelial cytosolic free Ca2+concentration (EC... -
Federal
Policy mapping for establishing a national emergency health policy for Nigeria
U.S. Department of Health & Human Services —
Background The number of potential life years lost due to accidents and injuries though poorly studied has resulted in tremendous economic and social loss to Nigeria.... -
Federal
Debate: A subversive view of subsets - a dissident clinician's opinion
U.S. Department of Health & Human Services —
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients... -
Federal
A comparison of volume control and pressure-regulated volume control ventilation in acute respiratory failure
U.S. Department of Health & Human Services —
Background: The aim of this study was to test the hypothesis that a new mode of ventilation (pressure-regulated volume control; PRVC) is associated with improvements... -
Federal
Ligamentous rupture of the ACL associated with dislocated fracture of the proximal tibial physis in a 12-year-old boy
U.S. Department of Health & Human Services —
Background Dislocated fracture of the proximal physeal plate of the tibia with or without metaphyseal fragment is rare in children. This unusual fracture classically... -
Federal
Continuous haemofiltration in the intensive care unit
U.S. Department of Health & Human Services —
Continuous renal replacement therapy (CRRT) was first described in 1977 for the treatment of diuretic-unresponsive fluid overload in the intensive care unit (ICU).... -
Federal
The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study
U.S. Department of Health & Human Services —
Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this... -
Federal
Activation of the peroxisome proliferator-activated receptor α protects against myocardial ischaemic injury and improves endothelial vasodilatation
U.S. Department of Health & Human Services —
Background The peroxisome proliferator-activated receptor α (PPARα) plays an important role in the metabolism of lipoproteins and fatty acids, and seems to protect... -
Federal
The genetics of chronic obstructive pulmonary disease
U.S. Department of Health & Human Services —
Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families,... -
Federal
Autoantibody profiling for the study and treatment of autoimmune disease
U.S. Department of Health & Human Services —
Proteomics technologies enable profiling of autoantibody responses using biological fluids derived from patients with autoimmune disease. They provide a powerful tool... -
Federal
Sex differences in risk factors for coronary heart disease: a study in a Brazilian population
U.S. Department of Health & Human Services —
Background In Brazil coronary heart disease (CHD) constitutes the most important cause of death in both sexes in all the regions of the country and interestingly, the...