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Federal
Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture
U.S. Department of Health & Human Services —
Background Inflammatory cells are believed to play a prominent role during tissue repair and remodeling. Since repair processes develop and mature over extended time... -
Federal
Physiological function of the maltose operon regulator, MalR, in
U.S. Department of Health & Human Services —
Background Maltose metabolism is initiated by an ATP-dependent permease system in Lactococcus lactis. The subsequent degradation of intracellular maltose is performed... -
Federal
Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
U.S. Department of Health & Human Services —
Background Nicotine is a psychoactive drug presenting a diverse array of biological activities, some positive, such as enhancement of cognitive performances, others... -
Federal
A missense mutation (Q279R) in the Fumarylacetoacetate Hydrolase gene, responsible for hereditary tyrosinemia, acts as a splicing mutation
U.S. Department of Health & Human Services —
Background Tyrosinemia type I, the most severe disease of the tyrosine catabolic pathway is caused by a deficiency in fumarylacetoacetate hydrolase (FAH). A patient... -
Federal
Conservation of the binding site for the arginine repressor in all bacterial lineages
U.S. Department of Health & Human Services —
Background: The arginine repressor ArgR/AhrC is a transcription factor universally conserved in bacterial genomes. Its recognition signal (the ARG box), a weak... -
Federal
Sex steroids do not affect shigatoxin cytotoxicity on human renal tubular or glomerular cells
U.S. Department of Health & Human Services —
Background The greater susceptibility of children to renal injury in post-diarrheal hemolytic-uremic syndrome (HUS) may be related, at least in part, to heightened... -
Federal
Conservation of long-range synteny and microsynteny between the genomes of two distantly related nematodes
U.S. Department of Health & Human Services —
To assess whether the pattern of high rates of genome rearrangement, with a bias towards within-chromosome events is true of nematodes in general, genome sequence was... -
Federal
Percutaneous tracheostomy: comparison of Ciaglia and Griggs techniques
U.S. Department of Health & Human Services —
Background: Although the standard tracheostomy described in 1909 by Jackson has been extensively used in critical patients, a more simple procedure that can be... -
Federal
Conservation of the COP9/signalosome in budding yeast
U.S. Department of Health & Human Services —
Background The COP9/signalosome (CSN), a multiprotein complex consisting of eight subunits, is implicated in a wide variety of regulatory processes including cell... -
Federal
Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
U.S. Department of Health & Human Services —
Background The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when... -
Federal
Is albumin gradient or fluid to serum albumin ratio better than the pleural fluid lactate dehydroginase in the diagnostic of separation of pleural effusion?
U.S. Department of Health & Human Services —
Background To determine the accuracy of serum-effusion albumin gradient (SEAG) and pleural fluid to serum albumin ratio (ALBR) in the diagnostic separation of pleural... -
Federal
Detection of fast light-activated H
U.S. Department of Health & Human Services —
Background Proteorhodopsin (pR) is a light-activated proton pump homologous to bacteriorhodopsin and recently discovered in oceanic γ-proteobacteria. One perplexing... -
Federal
Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120
U.S. Department of Health & Human Services —
Background Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the... -
Federal
Diversity and abundance of bacteria in an underground oil-storage cavity
U.S. Department of Health & Human Services —
Background Microorganisms inhabiting subterranean oil fields have recently attracted much attention. Since intact groundwater can easily be obtained from the bottom... -
Federal
Lack of association between estrogen receptor β dinucleotide repeat polymorphism and autoimmune thyroid diseases in Japanese patients
U.S. Department of Health & Human Services —
Background The autoimmune thyroid diseases (AITDs), such as Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex... -
Federal
Lack of agreement between tonometric and gastric juice partial carbon dioxide tension
U.S. Department of Health & Human Services —
Our goal was to compare measurement of tonometered saline and gastric juice partial carbon dioxide tension (PCO2). In this prospective observational study, 112 pairs... -
Federal
Impact of renal dysfunction on weaning from prolonged mechanical ventilation
U.S. Department of Health & Human Services —
Background: In the intensive care unit (ICU) setting, the combination of mechanical ventilation and renal replacement therapy (RRT) has been associated with prolonged... -
Federal
Delta-Notch signaling and lateral inhibition in zebrafish spinal cord development: Correction
U.S. Department of Health & Human Services —
Delta-Notch signaling and lateral inhibition in zebrafish spinal cord development: Correction -
Federal
Locations of several novel 2'-
U.S. Department of Health & Human Services —
Background Ribose 2'-O-methylation, the most common nucleotide modification in mammalian rRNA, is directed by the C/D box small nucleolar RNAs (snoRNAs). Thus far,... -
Federal
Central effects of clozapine in regulating micturition in anesthetized rats
U.S. Department of Health & Human Services —
Background We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited...