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Federal
Modulation of L-type Ca
U.S. Department of Health & Human Services —
Background The multisubunit (α1S,α2-δ, β1a and γ1) skeletal muscle dihydropyridine receptor (DHPR) transduces membrane depolarization into release of Ca2+ from the... -
Federal
Cost effectiveness in treating ventilator-associated pneumonia
U.S. Department of Health & Human Services —
Ventilator-associated pneumonia is a common illness in intensive care unit patients. The costs of management are increased when infection involves resistant... -
Federal
Analysis of stress- and host cell-induced expression of the
U.S. Department of Health & Human Services —
Background The gene encoding the inorganic pyrophosphatase (PPase) of the intracellular pathogen Legionella pneumophila is induced during intracellular infection, but... -
Federal
Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction
U.S. Department of Health & Human Services —
In the present study, we searched for mutant PTEN transcripts in aggressive rheumatoid arthritis synovial fibroblasts (RA-SF) and studied the expression of PTEN in... -
Federal
The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates
U.S. Department of Health & Human Services —
Background: Uracil DNA glycosylases (UDGs) are major repair enzymes that protect DNA from mutational damage caused by uracil incorporated as a result of a polymerase... -
Federal
Cultured Kaposi's sarcoma tumor cells exhibit a chemokine receptor repertoire that does not allow infection by HIV-1
U.S. Department of Health & Human Services —
Background HIV-1 is known to play a critical role in the pathogenesis of AIDS-associated Kaposi's sarcoma (KS). However, it remains controversial whether KS cells are... -
Federal
Interkingdom gene fusions
U.S. Department of Health & Human Services —
Background: Genome comparisons have revealed major lateral gene transfer between the three primary kingdoms of life - Bacteria, Archaea, and Eukarya. Another... -
Federal
Selective alteration of gene expression in response to natural and synthetic retinoids.
U.S. Department of Health & Human Services —
Background Retinoids are very potent inducers of cellular differentiation and apoptosis, and are efficient anti-tumoral agents. Synthetic retinoids are designed to... -
Federal
Primary biliary cirrhosis and autoimmune cholangitis are not associated with coeliac disease in Crete
U.S. Department of Health & Human Services —
Background An increased prevalence of coeliac disease in patients with primary biliary cirrhosis has been recently reported. However, in other studies the association... -
Federal
Gastric stimulation: influence of electrical parameters on gastric emptying in control and diabetic rats
U.S. Department of Health & Human Services —
Background The aim of this study was to test the effect of different pulse frequencies and amplitudes during gastric stimulation (GS) on gastric emptying in the rat.... -
Federal
Research Article: BMC Genomics
U.S. Department of Health & Human Services —
Background Gonadotropin releasing hormone (GnRH) is responsible for stimulation of gonadotropic hormone (GtH) in the hypothalamus-pituitary-gonadal axis (HPG). The... -
Federal
Phylogenetic analysis of methanogens from the bovine rumen
U.S. Department of Health & Human Services —
Background Interest in methanogens from ruminants has resulted from the role of methane in global warming and from the fact that cattle typically lose 6 % of ingested... -
Federal
Digital analysis of cDNA abundance; expression profiling by means of restriction fragment fingerprinting
U.S. Department of Health & Human Services —
Background Gene expression profiling among different tissues is of paramount interest in various areas of biomedical research. We have developed a novel method (DADA,... -
Federal
Speciality status for intensive care medicine?
U.S. Department of Health & Human Services —
Speciality status for intensive care medicine? -
Federal
IFN-gamma transgenic mice: clues to the pathogenesis of systemic lupus erythematosus?
U.S. Department of Health & Human Services —
Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months... -
Federal
Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study
U.S. Department of Health & Human Services —
Background: The aim of this prospective study was to assess whether the presence of septic shock could influence the dose response to inhaled nitric oxide (NO) in NO-... -
Federal
A search for reverse transcriptase-coding sequences reveals new non-LTR retrotransposons in the genome of
U.S. Department of Health & Human Services —
Background: Non-long terminal repeat (non-LTR) retrotransposons are eukaryotic mobile genetic elements that transpose by reverse transcription of an RNA intermediate.... -
Federal
Role of epidermal growth factor receptor activation in regulating mucin synthesis
U.S. Department of Health & Human Services —
Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion,... -
Federal
Effects of Cu
U.S. Department of Health & Human Services —
Background Heavy metals, especially copper, nickel, lead and zinc, have adverse effects on terrestrial and in aquatic environments. However, their impact can vary... -
Federal
Design and intermediate results of the Lower Extremity Arterial Disease Event Reduction (LEADER)* trial of bezafibrate in men with lower extremity arterial disease [ISRCTN41194621]
U.S. Department of Health & Human Services —
Background Raised levels of both triglycerides and fibrinogen, each of which are reduced by bezafibrate, may contribute to lower extremity arterial disease (LEAD)....