Find state-level estimates for 35 measures of substance use and mental health from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). These estimates are based on small area estimation (SAE) methods in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled state estimates of the civilian, noninstitutionalized population ages 12 and older.Along with the estimates, the collection includes an overview of the estimation methodology, a review of other state-level substance use and mental health data sources, and a document describing the groups used for mapping. The data are available in several forms: images of national maps and tables both overall and by age. There are also tables of p-values indicating whether differences between particular geographies are statistically significant.The indicators are presented in the following 37 tables:Drug use and Perceived RiskIllicit Drug Use in the Past MonthMarijuana Use in the Past YearMarijuana Use in the Past MonthPerceptions of Great Risk from Smoking Marijuana Once a MonthFirst Use of Marijuana in the Past Year (among those at risk for initiation)Illicit Drug Use Other than Marijuana in the Past MonthCocaine Use in the Past YearPerceptions of Great Risk from using Cocaine Once a MonthHeroin Use in the Past YearPerceptions of Great Risk from Trying Heroin Once or TwiceHallucinogen Use in the Past YearMethamphetamine Use in the Past YearPrescription Pain Reliever Misuse in the Past YearOpioid Misuse in the Past YearAlcoholAlcohol Use in the Past MonthBinge Alcohol Use in the Past MonthPerceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a WeekAlcohol Use, Binge Alcohol Use in the Past Month, and Perceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week (among people aged 12 to 20)TobaccoTobacco Product Use in the Past MonthCigarette Use in the Past MonthPerceptions of Great Risk from Smoking One or More Packs of Cigarettes per DaySubstance Use DisordersSubstance Use Disorder in the Past YearAlcohol Use Disorder in the Past YearAlcohol Use Disorder in the Past Year (among people aged 12 to 20)Drug Use Disorder in the Past YearPain Reliever Use Disorder in the Past YearOpioid Use Disorder in the Past YearSubstance Use TreatmentReceived Substance Use Treatment in the Past YearClassified as Needing Substance Use Treatment in the Past YearDid Not Receive Substance Use Treatment in the Past Year among those Classified as Needing Substance Use TreatmentMental IllnessAny Mental Illness in the Past YearSerious Mental Illness in the Past YearReceived Mental Health Treatment in the Past YearMajor Depressive Episode in the Past YearSuicidalityHad Serious Thoughts of Suicide in the Past YearMade Any Suicide Plans in the Past YearAttempted Suicide in the Past Year