This USGS data release includes a shapefile of outlet point locations for selected 12-digit hydrologic units (HU12s) from the Watershed Boundary Dataset (WBD), dated August 13, 2020 (U.S. Geological Survey and others, 2020), draining to the Gulf of Mexico in the south-central and southeastern United States. The outlet locations were derived by combining the WBD boundaries with flow direction grids from the National Hydrography Dataset Plus (NHDPlus) v 2.1 (U.S. Environmental Protection Agency and U.S. Geological Survey, 2012). Most of the outlet locations were determined by finding the cell with highest flow accumulation from the NHDPlus flow-direction grids within each WBD HU12 boundary. Some locations were found to be inaccurate upon inspection, and other sources were used for the locations as described in the attribute description and process description sections of this document. A shapefile of the HU12 boundaries from the WBD (U.S. Geological Survey and others, 2020) for the study area also is included in this data release for comparison to outlet locations. References cited: U.S. Environmental Protection Agency and U.S. Geological Survey, 2012, National Hydrography Dataset Plus - NHDPlus, version 2.1, accessed August 2020 at https://nhdplus.com/NHDPlus/NHDPlusV2_data.php. U.S. Geological Survey, U.S. Department of Agriculture - Natural Resource Conservation Service, U.S. Environmental Protection Agency, and other Federal, State, and local partners, 2020, Watershed Boundary Dataset - WBD, accessed August 2020 at https://apps.nationalmap.gov/viewer/.