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Background The multisubunit (α1S,α2-δ, β1a and γ1) skeletal muscle dihydropyridine receptor (DHPR) transduces membrane depolarization into release of Ca2+ from the sarcoplasmic reticulum...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: September 07, 2025 at 11:24 AM -
Background Expression of transgenes in mice requires transcriptional regulatory elements that direct expression in a chosen cell type. Unfortunately, the availability of...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: September 07, 2025 at 10:50 PM -
Background Gene targeting would offer a number of advantages over current transposon-based strategies for insect transformation. These include freedom from both position effects...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: September 07, 2025 at 09:31 PM -
Background A third DNA strand can bind into the major groove of a homopurine duplex DNA to form a DNA triple helix. Sequence specific triplex formation can be applied for gene targeting,...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: September 07, 2025 at 04:04 PM -
Background Recent progress in insect transgenesis has been dramatic but existing transposon-based approaches are constrained by position effects and potential instability. Gene targeting...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: September 07, 2025 at 07:28 AM
