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The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17...
Search relevance: 1.00 | Views last month: 3 | Catalog Last Checked: September 10, 2026 at 08:20 PM -
Bone resorption in the joints is the characteristic finding in patients with rheumatoid arthritis (RA). Osteoclast-like cells are present in the synovial tissues and invade the bone of patients...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 08:33 PM -
Background Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact mechanism of action of...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 08:28 PM -
Background Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 07:46 PM -
Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering...
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Background Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: September 10, 2026 at 07:39 PM -
Bone-resorbing osteoclasts are formed from hemopoietic cells of the monocyte–macrophage lineage under the control of bone-forming osteoblasts. We have cloned an osteoblast-derived factor essential...
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The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the identification of factors...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: September 10, 2026 at 07:53 PM
