{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Katie Friedman", "hasEmail": "mailto:paul-friedman.katie@epa.gov"}, "description": "Dataset for 'A high throughput screening assay for human Thyroperoxidase inhibitors' by Hongyan Dong, et al., a collaboration work with primary authorship at Health Canada. Published in Toxicology in Vitro, Vol 101, 105946, Dec 2024; DOI https://doi.org/10.1016/j.tiv.2024.105946. Supplementary Data File 1: Examples of two solution plates and the resulting assay plate layouts for Single concentration phase. Supplementary Data File 2: The tcpl analyses of all multiple concentration phase data including plots of fitted models, estimates of log AC50 (ga), and hit call. Supplementary Data File 3: Supplementary Tables 1-5. For further data, please contact corresponding author Hongyan Dong at email Hongyan.Dong@hc-sc.gc.ca. \n\nThis dataset is associated with the following publication:\nDong, H., K. Friedman, A. Filiatreault, E. Thomson, and M. Wade. A high throughput screening assay for human Thyroperoxidase inhibitors.   TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 101: 105946, (2024).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532100/1-s2.0-S0887233324001760-Supplement1.docx", "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "title": "1-s2.0-S0887233324001760-Supplement1.docx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532100/1-s2.0-S0887233324001760-Supplement2.pdf", "mediaType": "application/pdf", "title": "1-s2.0-S0887233324001760-Supplement2.pdf"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532100/1-s2.0-S0887233324001760-Supplement3.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "1-s2.0-S0887233324001760-Supplement3.xlsx"}], "identifier": "https://doi.org/10.23719/1532100", "keyword": ["Screening assay", "Thyroid peroxidase", "endocrine disruption", "thyroid hormone"], "license": "https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html", "modified": "2024-07-16", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1016/j.tiv.2024.105946"], "rights": null, "title": "A high throughput screening assay for human Thyroperoxidase inhibitors"}