{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Objectives:\n          The relation of procalcitonin (PCT) plasma concentrations compared\n\t\t\t\twith C-reactive protein (CRP) was analyzed in patients with different severity\n\t\t\t\tof multiple organ dysfunction syndrome (MODS) and systemic inflammation.\n        \n        \n          Patients and methods:\n          PCT, CRP, the sepsis-related organ failure assessment (SOFA)\n\t\t\t\tscore, the Acute Physiology, Age, Chronic Health Evaluation (APACHE) II score\n\t\t\t\tand survival were evaluated in 40 patients with systemic inflammation and\n\t\t\t\tconsecutive MODS over a period of 15 days.\n        \n        \n          Results:\n          Higher SOFA score levels were associated with significantly higher\n\t\t\t\tPCT plasma concentrations (SOFA 7-12: PCT 2.62 ng/ml, SOFA 19-24: PCT\n\t\t\t\t15.22 ng/ml) (median), whereas CRP was elevated irrespective of the scores\n\t\t\t\tobserved (SOFT 7-12: CRP 131 mg/l, SOFT 19-24: CRP 135 mg/l). PCT of\n\t\t\t\tnon-surviving patients was initially not different from that of survivors but\n\t\t\t\tsignificantly increased after the fourth day following onset of the disease,\n\t\t\t\twhereas CRP was not different between both groups throughout the whole\n\t\t\t\tobservation period.\n        \n        \n          Conclusions:\n          Measurement of PCT concentrations during multiple organ\n\t\t\t\tdysfunction syndrome provides more information about the severity and the\n\t\t\t\tcourse of the disease than that of CRP. Regarding the strong association of PCT\n\t\t\t\tand the respective score systems in future studies we recommend evaluation also\n\t\t\t\tof the severity of inflammation and MODS when PCT concentrations were compared\n\t\t\t\tbetween different types of disease.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29013/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/4eq2-gmw8", "issued": "2025-07-13", "keyword": ["crp-levels", "nih", "procalcitonin-levels", "sepsis-markers", "sofa-score"], "landingPage": "https://healthdata.gov/d/4eq2-gmw8", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma\n\t\t  concentrations at different SOFA scores during the course of sepsis and\n\t\t  MODS"}