{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Roman Mezencev", "hasEmail": "mailto:mezencev.roman@epa.gov"}, "describedBy": "https://pasteur.epa.gov/uploads/10.23719/1504295/documents/Mezencev_Auerbach_Data_Dictionary.docx", "describedByType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "description": "This dataset is a project file generated by BMDExpress 2.2 SW  (Sciome, Research Triangle Park, NC). It contains gene expression data for livers of rats exposed to 4 chemicals (crude MCHM, neat MCHM, DMPT, p-toluidine) and kidneys of rats exposed to PPH. The project file includes normalized expression data (GeneChip Rat 230 2.0 Array) using 7 different pre-processing methods (RMA, GCRMA, MAS5.0, MAS5.0_noA calls, PLIER, PLIER16, and PLIER16_noA calls); differentially expressed probe-sets detected by William's method (p<0.05, and minimum fold change of 1.5); probeset-level and pathway-level BMD and BMDL values from transcriptomic dose-response modeling. \n\nThis dataset is associated with the following publication:\nMezencev, R., and S. Auerbach. The sensitivity of transcriptomics BMD modeling to the methods used for microarray data normalization.   PLOS ONE. Public Library of Science, San Francisco, CA, USA, 15(5): e0232955, (2020).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504295/Mezencev_Auerbach_5_cmpds_7_normalizations_BMDExpress.zip", "mediaType": "application/x-zip-compressed", "title": "Mezencev_Auerbach_5_cmpds_7_normalizations_BMDExpress.zip"}], "identifier": "https://doi.org/10.23719/1504295", "keyword": ["dose-response modeling", "microarray", "toxicogenomics"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2018-08-30", "programCode": ["020:062"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1371/journal.pone.0232955"], "rights": null, "title": "The sensitivity of transcriptomics BMD modeling to the methods used for microarray data normalization"}