{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Urmila Kodavanti", "hasEmail": "mailto:kodavanti.urmila@epa.gov"}, "description": "In this study, we investigated effects of inhaled ozone exposure and high-cholesterol diet (HCD) in healthy Wistar and Wistar-derived Goto-Kakizaki (GK) rats, a non-obese model of type 2 diabetes. Male rats (4-week old) were fed normal diet or HCD for 12 weeks and then exposed to filtered air or 1.0 ppm ozone (6hrs/day) for 1 or 2 days. We examined pulmonary, vascular, hematology, and inflammatory responses after each exposure plus an 18-hr recovery period. \n\nThis dataset is associated with the following publication:\nSnow, S., A. Henriquez, L. Thompson, C. Fisher, M.C. Schladweiler, C. Wood, and U. Kodavanti. Pulmonary and Vascular Effects of Acute Ozone Exposure in Diabetic Rats Fed an Atherogenic Diet.   TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 415(115430): 1, (2021).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1521140/GK-ozone%20Pulmonary%20Paper%20Science%20Hub-final.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "GK-ozone Pulmonary Paper Science Hub-final.xlsx"}], "identifier": "https://doi.org/10.23719/1521140", "keyword": ["Western high-cholesterol diet", "pulmonary injury", "systemic inflammation", "type 2 diabetes rat model", "vasocontraction"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2020-11-30", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1016/j.taap.2021.115430"], "rights": null, "title": "Pulmonary and Vascular Effects of Acute Ozone Exposure in Diabetic Rats Fed an Atherogenic Diet"}