{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH/NCBI Data Team", "hasEmail": "mailto:info@ncbi.nlm.nih.gov"}, "description": "The present invention discloses the differential expression of the gene coding for the nuclear restricted protein/brain, NRP/B, in specific brain regions of Alzheimer's disease patients. Based on this finding this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for a nuclear restricted protein, in particular the nuclear restricted protein/brain, NRP/B. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.", "distribution": [{"@type": "dcat:Distribution", "description": "Access the complete Patent AT-E401576-T1: [Translated] USE OF A NUCLEAR-RESTRICTED PROTEIN FOR THE DIAGNOSIS AND THERAPY OF ALZHEIMER'S DISEASE AND RELATED DEEP NEURODEGENERATION DISORDERS on the official website.", "downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E401576-T1", "mediaType": "text/html", "title": "Official Data Source"}], "identifier": "https://healthdata.gov/api/views/k587-3mr5", "issued": "2025-09-05", "keyword": ["chemistry", "innovation", "patent", "pubchem", "research"], "landingPage": "https://healthdata.gov/d/k587-3mr5", "modified": "2025-09-06", "programCode": ["009:066"], "publisher": {"@type": "org:Organization", "name": "National Center for Biotechnology Information (NCBI)"}, "theme": ["NIH"], "title": "Patent AT-E401576-T1: [Translated] USE OF A NUCLEAR-RESTRICTED PROTEIN FOR THE DIAGNOSIS AND THERAPY OF ALZHEIMER'S DISEASE AND RELATED DEEP NEURODEGENERATION DISORDERS"}