{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background:\n          Glucose tolerance (GT) has not been taken into consideration in \ninvestigations concerning relationships between coagulopathy and multiple organ \ndysfunction syndrome (MODS), and endothelial cell activation/endothelial cell \ninjury (ECA/ECI) in septic patients, although coagulopathy is known to be \ninfluenced by blood glucose level. We investigated those relationships under \nstrict blood glucose control and evaluation of GT with the glucose clamp method \nby means of the artificial pancreas in nine septic patients with glucose \nintolerance. The relationships between GT and blood stress related hormone \nlevels (SRH) were also investigated.\n        \n        \n          Methods:\n          The amount of metabolized glucose (M value), as the parameter of \nGT, was measured by the euglycemic hyperinsulinemic glucose clamp method, in \nwhich the blood glucose level was clamped at 80 mg/dl under a continuous \ninsulin infusion rate of 1.12 mU/kg per min, using the artificial pancreas, \nSTG-22. Multiple organ failure (MOF) score was calculated using the MOF \ncriteria of Japanese Association for Critical Care Medicine. Regarding \ncoagulopathy, the following parameters were used: disseminated intravascular \ncoagulation (DIC) score (calculated from the DIC criteria of the Ministry of \nHealth and Welfare of Japan) and the parameters used for calculating DIC score, \nprotein-C, protein-S, plasminogen, antithrombin III (AT-III), plasminogen \nactivator inhibitor-1 (PAI-1), and tissue plasminogen activator-PAI-1 \n(tPA-PAI-1) complex. Thrombomodulin (TM) was measured as the indicator of \nECI.\n        \n        \n          Results:\n          There were no significant correlations between M value and SRH, \nparameters indicating coagulopathy and the MOF score. The MOF score and blood \nTM levels were positively correlated with DIC score, thrombin-AT-III complex \nand tPA-PAI-1 complex, and negatively correlated with blood platelet count.\n        \n        \n          Conclusions:\n          GT was not significantly related to SRH, coagulopathy and MODS under strict \nblood glucose control. Hypercoagulability was closely related to MODS and ECI. \nAmong the parameters indicating coagulopathy, tPA-PAI-1 complex, which is \nconsidered to originate from ECA, seemed to be a sensitive parameter of MODS \nand ECI, and might be a predictive marker of MODS. The treatment for reducing \nhypercoagulability and ECA/ECI were thought to be justified as one of the \ntherapies for acutely ill septic patients.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30714/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/kukr-jdrr", "issued": "2025-07-13", "keyword": ["glucose-tolerance", "multiple-organ-dysfunction", "nih", "septic-patients", "tissue-plasminogen-activator"], "landingPage": "https://healthdata.gov/d/kukr-jdrr", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Close relationship of tissue plasminogen activator-plasminogen \nactivator inhibitor-1 complex with multiple organ dysfunction syndrome \ninvestigated by means of the artificial pancreas"}