{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Thomas Knudsen", "hasEmail": "mailto:knudsen.thomas@epa.gov"}, "description": "The systems map described in this manuscript for neurulation will set the stage for constructing mathematical models and computer simulation of neural tube closure for human-relevant AOPs and predictive toxicology of neural tube defects such as spina bifida. This dataset is not publicly accessible because: The data for the systems map has been obtained from comprehensive literature review. It can be accessed through the following means: Contact the corresponding author Harm J. Heusinkveld, Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O.Box 1, 3720BA, Bilthoven, The Netherlands. Email: harm.heusinkveld@rivm.nl. Format: Not availabie. \n\nThis dataset is associated with the following publication:\nHeusinkveld, H., Y. Staal, N. Baker, G. Daston, T. Knudsen, and A. Piersma. An ontology for developmental processes and toxicities of neural tube closure.   REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 99: 160-167, (2021).", "distribution": [], "identifier": "https://doi.org/10.23719/1518767", "keyword": ["Predictive Toxicology", "developmental neurotoxicity", "neural tube defects", "retinoic acid", "systems biology", "virtual embryo"], "license": "https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html", "modified": "2020-05-26", "programCode": ["020:095"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1016/j.reprotox.2020.09.002"], "rights": null, "title": "An ontology for developmental processes and toxicities of neural tube closure"}