{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Leah Wehmas", "hasEmail": "mailto:wehmas.leah@epa.gov"}, "description": "RNA sequencing data from paired: (1) fresh-frozen, (2) direct-fixed in formalin for 18 hours, (3) frozen then formalin-fixed, or (4) frozen then ethanol-fixed and paraffin-embedded (n=6/group/condition) tissue samples from the livers of mice exposed to 600 ppm phenobarbital vs. vehicle control for 7 days in drinking water. RNA sequencing data from paired fresh frozen and 18 hr. formalin-fixed paraffin-embedded liver tissue from mice administered 1500, 3000, and 6000 ppm DEHP or vehicle control for 7 days by dietary ingestion; or RNA sequencing data from paired fresh frozen, 18 hr. formalin fixed paraffin embedded, or 3 wk. formalin fixed paraffin embedded liver tissue from mice administered 8 mg/kg/d Furan or vehicle control for 3 weeks by gavage. \n\nThis dataset is associated with the following publication:\nWehmas, L., S. Hester, and C.E. Wood. Direct Formalin Fixation Induces Widespread Transcriptomic Effects in Archival Tissue Samples.   Scientific Reports. Nature Publishing Group, London,  UK, 10: 14497, (2020).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effect_MS_Master_Table_20200728_complete.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Formalin_effect_MS_Master_Table_20200728_complete.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effect_MS_Master_Table_2_20200728.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Formalin_effect_MS_Master_Table_2_20200728.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effect_MS_Master_Table_3_20200728.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Formalin_effect_MS_Master_Table_3_20200728.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effect_MS_Master_Table_4_20200728.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Formalin_effect_MS_Master_Table_4_20200728.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effects_manuscript_supplementary_table_legends.docx", "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "title": "Formalin_effects_manuscript_supplementary_table_legends.docx"}], "identifier": "https://doi.org/10.23719/1518503", "keyword": ["DEHP", "Formalin-fixed paraffin embedded samples", "Gene expression profiles", "RNA-sequencing", "furan", "mode of action (MOA)", "molecular pathway analysis", "phenobarbital"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2020-04-21", "programCode": ["020:095"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1038/s41598-020-71521-w"], "rights": null, "title": "formalin effects data"}