{
  "accessLevel": "public",
  "bureauCode": [
    "020:00"
  ],
  "contactPoint": {
    "fn": "Urmila Kodavanti",
    "hasEmail": "mailto:kodavanti.urmila@epa.gov"
  },
  "description": "Employing acrolein, a potent airway irritant, and TCE, with low irritancy, authors hypothesized that airway injury and inflammation would be involved in eliciting neuroendocrine-mediated systemic alterations. Male and female Wistar-Kyoto rats were exposed nose-only to air, acrolein or trichloroethylene (TCE) in incremental concentrations over 30 min, followed by 3.5-hr exposure to the highest concentration (acrolein - 0.0, 0.1, 0.316, 1, 3.16 ppm; TCE - 0.0, 3.16, 10, 31.6, 100 ppm) while performing head-out plethysmography (HOP), and animals were necropsied immediately post-exposure to assess nasal and lung injury/inflammation, systemic neurohormones, circulating stress hormones and also metabolic hormones. \n\nThis dataset is associated with the following publication:\nAlewel, D., T. Jackson, S. Vance, M. Schladweiler, P. Evansky, A. Henriquez, R. Grindstaff, S. Gavett, and U. Kodavanti. Sex-specific respiratory and systemic endocrine effects of acute acrolein and trichloroethylene inhalation.   TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, USA, 382: 22-32, (2023).",
  "distribution": [
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528189/Alewel%20et%20al_Toxicology_Sciencehub.xlsx",
      "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
      "title": "Alewel et al_Toxicology_Sciencehub.xlsx"
    }
  ],
  "identifier": "https://doi.org/10.23719/1528189",
  "keyword": [
    "Nitrogen and Co-pollutants",
    "acrolein",
    "air pollution",
    "ambient air",
    "sex difference",
    "trichloroethylene"
  ],
  "license": "https://pasteur.epa.gov/license/sciencehub-license.html",
  "modified": "2022-11-07",
  "programCode": [
    "020:000"
  ],
  "publisher": {
    "name": "U.S. EPA Office of Research and Development (ORD)",
    "subOrganizationOf": {
      "name": "U.S. Environmental Protection Agency",
      "subOrganizationOf": {
        "name": "U.S. Government"
      }
    }
  },
  "references": [
    "https://doi.org/10.1016/j.toxlet.2023.05.005"
  ],
  "rights": null,
  "title": "Sex-specific respiratory and systemic stress effects of acute acrolein and trichloroethylene inhalation"
}