{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background:\n          That thrombocytopenia results in increased mortality or\n\t\t\t\ttransfusion requirements has not been confirmed by previous studies. We\n\t\t\t\tperformed a case-control study in which 36 patients who developed severe\n\t\t\t\tthrombocytopenia of less than 50\u00d7109 platelets/l were carefully\n\t\t\t\tmatched for the severity of underlying disease and other important\n\t\t\t\tvariables.\n        \n        \n          Results:\n          Seventeen (47%) thrombocytopenic patients died, versus 10 (28%)\n\t\t\t\tmatched control patients who were not thrombocytopenic.Nine pairs had a\n\t\t\t\tdiscordant outcome, and in eight of these pairs the thrombocytopenic patient\n\t\t\t\tdied (exact binomial probability 0.037). The estimated attributable mortality\n\t\t\t\twas 19.5% (95% confidence interval 3.2\u231335.8), and the estimated odds ratio was\n\t\t\t\t2.7 (95% confidence interval 1.02\u23137.10). Thrombocytopenic patients had\n\t\t\t\tcomparable values for severity of illness scores between day of admission and\n\t\t\t\tday of thrombocytopenia, in contrast with control patients who had a\n\t\t\t\tstatistically significant decrease in severity of illness scores during the\n\t\t\t\tsame period. Thirty (83%) of the thrombocytopenic patients required transfusion\n\t\t\t\tof blood products, versus 21 (58%) control patients (paired \u03c72\n\t\t\t\ttest 4.92, P < 0.04). The estimated attributable transfusion\n\t\t\t\trequirement was 25% (95% confidence interval 5.4\u231344.6), and the estimated odds\n\t\t\t\tratio was 1.52 (95 confidence interval 1.05\u23132.20).\n        \n        \n          Conclusion:\n          The present study suggests that thrombocytopenia of less than\n\t\t\t\t50 \u00d7 109 platelets/l may be a marker for more severe illness and\n\t\t\t\tincreased risk of death, rather than causative, because a true causal\n\t\t\t\trelationship is not established. Thrombocytopenia also leads to an excess of\n\t\t\t\tblood product consumption.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29031/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/jk28-pd3f", "issued": "2025-07-13", "keyword": ["case-control-study", "nih", "surgical-icu", "thrombocytopenia-mortality", "transfusion-requirements"], "landingPage": "https://healthdata.gov/d/jk28-pd3f", "modified": "2025-09-06", "programCode": ["009:034"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Thrombocytopenia in critically ill surgical patients: a case-control\n\t\t  study evaluating attributable mortality and transfusion requirements"}