{
  "@type": "Dataset",
  "accessRights": "public",
  "contactPoint": [
    {
      "@type": "Kind",
      "fn": "Health Effects Laboratory Divsion (HELD). Allergy and Clinical Immunology Branch (ACIB)",
      "hasEmail": "mailto:sa-cin-webteam@cdc.gov"
    }
  ],
  "creator": {
    "@type": "Agent",
    "name": "National Institute for Occupational Safety and Health"
  },
  "describedBy": {
    "@type": "Document",
    "accessURL": "https://stacks.cdc.gov/view/cdc/249268",
    "title": "Metadata on HTML Repository Page"
  },
  "description": "<b>Download the Dataset</b> decsribed here from <b>Data.cdc.gov</b> at <a href=\"https://data.cdc.gov/National-Institute-for-Occupational-Safety-and-Hea/Systemic-toxicity-induced-by-topical-application-o/37ui-3igt/about_data\"target=_blank\">https://data.cdc.gov/National-Institute-for-Occupational-Safety-and-Hea/Systemic-toxicity-induced-by-topical-application-o/37ui-3igt/about_data</a>.\nHeptafluorobutyric acid (PFBA) is a synthetic chemical belonging to the per- and polyfluoroalkyl substances (PFAS) group that includes over 5,000 chemicals. PFBA is a short-chain PFAS (C4) that has been labeled as a safer alternative to the legacy PFAS perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS) which have been linked to numerous health effects. This class of chemicals are incorporated into consumer products such as stain resistant carpeting and textiles, nanosprays, medical devices, and fire-fighting foams. There is a high potential for occupational exposure and in the environment, PFBA has been detected in a variety of water sources leading to concerns for dermal exposure, however, these studies are lacking. In previous studies from our lab, PFOA was demonstrated to be absorbed via the skin and immunomodulatory. In the present study, the systemic toxicity of a 28-day dermal PFBA (3.75-15% w/v, or 93.8-375 mg/kg/dose) exposure was evaluated in a murine model. [Description provided by NIOSH]",
  "distribution": [
    {
      "@type": "Distribution",
      "accessURL": "https://stacks.cdc.gov/view/cdc/249268",
      "describedBy": {
        "@type": "Document",
        "accessURL": "https://stacks.cdc.gov/view/cdc/249268",
        "title": "Metadata on HTML Repository Page"
      },
      "description": "<b>Download the Dataset</b> decsribed here from <b>Data.cdc.gov</b> at <a href=\"https://data.cdc.gov/National-Institute-for-Occupational-Safety-and-Hea/Systemic-toxicity-induced-by-topical-application-o/37ui-3igt/about_data\"target=_blank\">https://data.cdc.gov/National-Institute-for-Occupational-Safety-and-Hea/Systemic-toxicity-induced-by-topical-application-o/37ui-3igt/about_data</a>.\nHeptafluorobutyric acid (PFBA) is a synthetic chemical belonging to the per- and polyfluoroalkyl substances (PFAS) group that includes over 5,000 chemicals. PFBA is a short-chain PFAS (C4) that has been labeled as a safer alternative to the legacy PFAS perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS) which have been linked to numerous health effects. This class of chemicals are incorporated into consumer products such as stain resistant carpeting and textiles, nanosprays, medical devices, and fire-fighting foams. There is a high potential for occupational exposure and in the environment, PFBA has been detected in a variety of water sources leading to concerns for dermal exposure, however, these studies are lacking. In previous studies from our lab, PFOA was demonstrated to be absorbed via the skin and immunomodulatory. In the present study, the systemic toxicity of a 28-day dermal PFBA (3.75-15% w/v, or 93.8-375 mg/kg/dose) exposure was evaluated in a murine model. [Description provided by NIOSH]",
      "downloadURL": "https://data.cdc.gov/download/37ui-3igt/application%2Fx-zip-compressed",
      "format": "ZIP folder",
      "license": "https://creativecommons.org/public-domain/",
      "mediaType": "application/zip",
      "rights": [
        "Public Domain"
      ],
      "title": "Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model (dataset)"
    }
  ],
  "identifier": "https://www.cdc.gov/niosh/data/datasets/RD-1033-2022-0/",
  "inventoried": "2026-09-27",
  "issued": "2022-04-14",
  "keyword": [
    "Dermal exposures\nSkin exposure\nSynthetic materials\nOccupational exposure\nEnvironmental exposure\nAnimal studies\nTextiles\nPer- and polyfluoroalkyl substances\nPFAS\nToxic effects"
  ],
  "landingPage": {
    "@type": "Document",
    "accessURL": "https://stacks.cdc.gov/view/cdc/249268",
    "title": "Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model (dataset)"
  },
  "otherIdentifier": [
    {
      "@type": "OtherIdentifier",
      "notation": "https://data.cdc.gov/d/37ui-3igt",
      "type": "Data.CDC.gov dataset identifier"
    }
  ],
  "publisher": {
    "@type": "Organization",
    "name": "National Institute for Occupational Safety and Health (NIOSH)",
    "subOrganizationOf": [
      {
        "@type": "Organization",
        "name": "Centers for Disease Control and Prevention (CDC)",
        "subOrganizationOf": [
          {
            "@type": "Organization",
            "name": "U.S. Department of Health and Human Services"
          }
        ]
      }
    ]
  },
  "rights": [
    "Public Domain"
  ],
  "rightsHolder": [
    {
      "@type": "Organization",
      "name": "National Institute for Occupational Safety and Health"
    }
  ],
  "spatial": [
    {
      "@type": "Location",
      "prefLabel": "OSHA Region 3\nWest Virginia"
    }
  ],
  "theme": [
    {
      "@type": "Concept",
      "prefLabel": "Animals\nEnvironmental Exposure\nOccupational Exposure\nOccupational Health\nSafety\nSkin\nTextile Industry"
    }
  ],
  "title": "Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model (dataset)"
}