{
  "@type": "dcat:Dataset",
  "accessLevel": "public",
  "bureauCode": [
    "009:25"
  ],
  "contactPoint": {
    "@type": "vcard:Contact",
    "fn": "NIH",
    "hasEmail": "mailto:info@nih.gov"
  },
  "description": "Background:\n          Hepatic injury after ischemia/reperfusion is attributed to the\n\t\t\t\tdevelopment of oxygen free radical (OFR)-mediated lipid peroxidation - a\n\t\t\t\tprocess that can be measured through its byproducts, specifically\n\t\t\t\tmalondialdehyde. The use of free radical scavengers can offer significant\n\t\t\t\tprotection against OFR-induced liver injury. We hypothesize that a new potent\n\t\t\t\tOFR scavenger, polyethylene glycol-superoxide dismutase (PEG-SOD), can inhibit\n\t\t\t\tOFR-mediated lipid peroxidation in hepatic ischemia/reperfusion injury.\n        \n        \n          Methods:\n          Twelve male Sprague-Dawley rats (300-350 g) were subjected to\n\t\t\t\tocclusion of the left and middle hepatic arteries and portal veins for 90 min,\n\t\t\t\tfollowed by 120 min reperfusion. PEG-SOD (5000 units/kg) was given intravenously\n\t\t\t\tbefore vascular occlusion and again immediately upon reperfusion to six rats.\n\t\t\t\tNormal saline was given to the remaining six rats to be used as a control\n\t\t\t\tgroup. The right hepatic lobe (used as internal control) and left hepatic lobe\n\t\t\t\twere harvested separately and tissue malondialdehyde was measured.\n        \n        \n          Results:\n          A marked increase in lipid peroxide was found in the normal saline\n\t\t\t\tgroup after 2 h reperfusion. Treatment with PEG-SOD prevented the rise in tissue\n\t\t\t\tmalondialdehyde. The mean difference in the malondialdehyde between the left\n\t\t\t\tand right hepatic lobes were 13.20 ± 6.35 and 1.70 ± 3.65 nmol/g in the\n\t\t\t\tnormal saline (control) and PEG-SOD groups, respectively. This difference was\n\t\t\t\tfound to be statistically significant (P < 0.005) using\n\t\t\t\tStudent's t-test.\n        \n        \n          Conclusions:\n          PEG-SOD can effectively attenuate hepatic ischemia/reperfusion\n\t\t\t\tinjury by inhibiting OFR-mediated lipid peroxidation.",
  "distribution": [
    {
      "@type": "dcat:Distribution",
      "description": "Visit the original government dataset for complete information, documentation, and data access.",
      "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29026/",
      "mediaType": "text/html",
      "title": "Official Government Data Source"
    }
  ],
  "identifier": "https://healthdata.gov/api/views/2fab-r5gs",
  "issued": "2025-07-13",
  "keyword": [
    "hepatic-ischemia",
    "lipid-peroxidation",
    "nih",
    "peg-sod",
    "reperfusion-injury"
  ],
  "landingPage": "https://healthdata.gov/d/2fab-r5gs",
  "modified": "2025-09-06",
  "programCode": [
    "009:033"
  ],
  "publisher": {
    "@type": "org:Organization",
    "name": "National Institutes of Health"
  },
  "theme": [
    "NIH"
  ],
  "title": "Polyethylene glycol-superoxide dismutase inhibits lipid peroxidation\n\t\t  in hepatic ischemia/reperfusion injury"
}