{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background:\n          Adequate humidification in long-term jet ventilation is a critical\n\t\t\t\taspect in terms of clinical safety.\n        \n        \n          Aim:\n          To assess a prototype of an electronic jet-ventilator and its\n\t\t\t\thumidification system.\n        \n        \n          Methods:\n          Forty patients with respiratory insufficiency were randomly\n\t\t\t\tallocated to one of four groups. The criterion for inclusion in this study was\n\t\t\t\trespiratory insufficiency exhibiting a Murray score above 2. The four groups of\n\t\t\t\tpatients were ventilated with three different respirators and four different\n\t\t\t\thumidification systems. Patients in groups A and B received superimposed\n\t\t\t\thigh-frequency jet ventilation (SHFJV) by an electronic jet-ventilator either\n\t\t\t\twith (group A) or without (group B) an additional humidification system.\n\t\t\t\tPatients in group C received high-frequency percussive ventilation (HFPV) by a\n\t\t\t\tpneumatic high-frequency respirator, using a hot water humidifier for warming\n\t\t\t\tand moistening the inspiration gas. Patients in group D received conventional\n\t\t\t\tmechanical ventilation using a standard intensive care unit respirator with a\n\t\t\t\tstandard humidification system. SHFJV and HFPV were used for a period of 100 h\n\t\t\t\t(4days).\n        \n        \n          Results:\n          A significantly low inspiration gas temperature was noted in\n\t\t\t\tpatients in group B, initially (27.2 \u00b1 2.5\u00b0C) and after 2 days\n\t\t\t\t(28.0 \u00b1 1.6\u00b0C) (P < 0.05). The percentage of relative\n\t\t\t\thumidity of the inspiration gas in patients in group B was also initially\n\t\t\t\tsignificantly low (69.8 \u00b1 4.1%; P < 0.05) but rose to an average\n\t\t\t\tof 98 \u00b1 2.8% after 2 h. The average percentage across all four groups\n\t\t\t\tamounted to 98 \u00b1 0.4% after 2 h. Inflammation of the tracheal mucosa was\n\t\t\t\tfound in patients in group B and the mucosal injury score (MIS) was\n\t\t\t\tsignificantly higher than in all the other groups. Patients in groups A, C and\n\t\t\t\tD showed no severe evidence of airway damage, exhibiting adequate values of\n\t\t\t\trelative humidity and temperature of the inspired gas.\n        \n        \n          Conclusion:\n          The problems of humidification associated with jet ventilation can\n\t\t\t\tbe fully prevented by using this new jet-ventilator. These data were sustained\n\t\t\t\tby nondeteriorating MIS values at the end of the 4-day study period in groups\n\t\t\t\tA, C and D.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29022/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/88th-e3vj", "issued": "2025-07-13", "keyword": ["humidification-systems", "jet-ventilation", "mechanical-ventilation", "nih", "respiratory-insufficiency"], "landingPage": "https://healthdata.gov/d/88th-e3vj", "modified": "2025-09-06", "programCode": ["009:039"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "A new prototype of an electronic jet-ventilator and its humidification\n\t\t  system"}