{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "CD8+ T cells dominate the lymphocyte population in\nsynovial fluid in chronic inflammatory arthritis. It is known that these\nCD8+ T cells are often clonally or oligoclonally expanded, but their\nspecificity and their relevance to the pathogenesis of joint disease has\nremained unclear. We found that as many as 15.5% of synovial CD8+ T\ncells may be specific for a single epitope from an Epstein-Barr virus lytic\ncycle protein. The virus-specific T cells within the joint showed increased\nexpression of markers of activation and differentiation compared with those in\nthe periphery, and retained their functional capacity to secrete\nproinflammatory cytokines on stimulation. These activated, virus-specific\nCD8+ T cells could therefore interact with synoviocytes, either by\ncell-cell contact or by a cytokine network, and play a 'bystander'\nrole in the maintenance of inflammation in patients with arthritis.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17809/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/ytrg-6pdp", "issued": "2025-07-13", "keyword": ["cd8-t-cells", "epstein-barr-virus", "nih", "rheumatoid-arthritis", "synovial-fluid"], "landingPage": "https://healthdata.gov/d/ytrg-6pdp", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Specificity of T cells in synovial fluid: high frequencies of\n\t\t  CD8"}