{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Objective:\n          To non-invasively study the effects of continuous positive airway\n\t\t\t\tpressure breathing (CPAP) on renal vascular resistance in normal subjects and\n\t\t\t\trenal allograft recipients, in other words those with with denervated kidneys.\n\t\t\t\tWe could then ascertain the influence of renal innervation on any resulting\n\t\t\t\tchanges in renal haemodynamics.\n        \n        \n          Methods:\n          Ten healthy volunteers and six renal transplant patients were\n\t\t\t\tstudied. Using Doppler ultrasonography, the pulsatility index (PI), an index of\n\t\t\t\trenovascular resistance, was measured at incremental levels of CPAP (0, 2.5,\n\t\t\t\t5.0 and 7.5 cmH2O).\n        \n        \n          Results:\n          In both groups, the PI increased significantly between 0 and\n          5.0 cmH2O CPAP, with a further increase at 7.5 cmH2O CPAP.\n        \n        \n          Conclusions:\n          We found that CPAP at 5.0 and 7.5 cmH2O caused a\n\t\t\t\tsignificant increase in renovascular resistance in both normal and renal\n\t\t\t\ttransplant patients. There was no difference in the degree of rise in\n\t\t\t\trenovascular resistance between both groups, indicating that the renal nerves\n\t\t\t\tdo not play a role in altering renal vascular resistance with the application\n\t\t\t\tof CPAP.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29011/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/3kkw-y2zw", "issued": "2025-07-13", "keyword": ["cpap-therapy", "doppler-ultrasonography", "nih", "renal-transplant", "renal-vascular-resistance"], "landingPage": "https://healthdata.gov/d/3kkw-y2zw", "modified": "2025-09-06", "programCode": ["009:037"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "The effect of continuous positive airway pressure (CPAP) on renal\n\t\t  vascular resistance: the influence of renal denervation"}