{
  "accessLevel": "public",
  "bureauCode": [
    "020:00"
  ],
  "contactPoint": {
    "fn": "Katie Friedman",
    "hasEmail": "mailto:paul-friedman.katie@epa.gov"
  },
  "description": "Data for EPA collaboration with Case Western Reserve Univ, Erin Cohn, et al. 'Pervasive environmental chemicals impair oligodendrocyte development', DOI https://doi.org/10.1038/s41593-024-01599-2. \nPrimary screening results are available in Supplementary Table 1 and will be included in a future public release of the EPA ToxCast database. RNA-seq datasets generated in this study have been deposited in Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo) under accession code GSE244500. \n\nThis dataset is associated with the following publication:\nCohn, E., B. Clayton, M. Madhavan, K. Lee, S. Yacoub, Y. Fedorov  , M. Scavuzzo, K. Paul-Friedman, T. Shafer, and P. Tesar. Pervasive environmental chemicals impair oligodendrocyte development.   Nature Neuroscience. Nature Portfolio, Berlin,  GERMANY, 27(5): 836-845, (2024).",
  "distribution": [
    {
      "accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE244500",
      "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE244500"
    },
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1530984/Supplementary%20Table%201-%20Primary%20screening%20results.xlsx",
      "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
      "title": "Supplementary Table 1- Primary screening results.xlsx"
    },
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1530984/Supplementary%20Table%202-%20ToxPrint%20enrichment%20analysis.xlsx",
      "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
      "title": "Supplementary Table 2- ToxPrint enrichment analysis.xlsx"
    },
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1530984/Supplementary%20Table%203-%20Gene%20set%20enrichment%20analysis.xlsx",
      "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
      "title": "Supplementary Table 3- Gene set enrichment analysis.xlsx"
    }
  ],
  "identifier": "https://doi.org/10.23719/1530984",
  "keyword": [
    "cytotoxicity",
    "neurotoxicity",
    "oligodendrocytes",
    "screening"
  ],
  "license": "https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html",
  "modified": "2024-01-23",
  "programCode": [
    "020:000"
  ],
  "publisher": {
    "name": "U.S. EPA Office of Research and Development (ORD)",
    "subOrganizationOf": {
      "name": "U.S. Environmental Protection Agency",
      "subOrganizationOf": {
        "name": "U.S. Government"
      }
    }
  },
  "references": [
    "https://doi.org/10.1038/s41593-024-01599-2",
    "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11088982"
  ],
  "rights": null,
  "title": "Pervasive environmental chemicals impair oligodendrocyte development"
}