{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background\n          Infants usually respond differently to a neuromuscular relaxant compared to children or adults. Isoflurane is commonly used as an anesthetic gas in infants. In an RCT design, we investigated whether a dose of mivacurium 250 \u03bcg/kg results in faster onset of action than 200 \u03bcg/kg in infants under isoflurane anesthesia. Spontaneous recovery times and cardiovascular response were also evaluated.\n        \n        \n          Methods\n          Twenty-four low surgical risk children, aged 6\u201324 months, undergoing an elective surgery and requiring tracheal intubation were selected. After anesthetic induction, patients randomly received an iv bolus dose of mivacurium 200 or 250 \u03bcg/kg. After maximal relaxation, the patient was intubated. Isoflurane was administered to maintain anesthetic level during the surgical procedure. Neuromuscular function was monitored by accelerometry (TOF-Guard) at the adductor pollicies. The first twitch (T) of the TOF and the T4/T1 were measured. The time-course of heart rate and systolic and diastolic blood pressure were analysed by transforming them into their respective areas under the curve.\n        \n        \n          Results\n          Mivacurium 250 \u03bcg/kg produced a maximal T block faster than 200 \u03bcg/kg, i.e. 2.4 \u00b1 1.1 vs. 3.5 \u00b1 1.4 min (p < 0.05). Spontaneous recovery times were similar in both groups. Heart rate was similar between doses while systolic and diastolic blood pressures were lower with the higher dose (p < 0.05). Flushing was observed in two cases, one in each group.\n        \n        \n          Conclusions\n          The maximal effect of mivacurium 250 \u03bcg/kg, in infants under isoflurane anesthesia, was present one minute faster than 200 \u03bcg/kg. However, it produced a significant cardiovascular response.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC60007/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/d3h5-reay", "issued": "2025-07-14", "keyword": ["infant-anesthesia", "isoflurane-anesthesia", "mivacurium-dosage", "neuromuscular-blockade", "nih"], "landingPage": "https://healthdata.gov/d/d3h5-reay", "modified": "2025-09-06", "programCode": ["009:032"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Effect of mivacurium 200 and 250 \u03bcg/kg in infants during isoflurane anesthesia: a randomized controlled trial [ISRCTN07742712]"}