{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Thomas Knudsen", "hasEmail": "mailto:knudsen.thomas@epa.gov"}, "description": "This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, \"Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes.\" Using in vitro data to estimate point of departure (POD) values is an important component of new approach method (NAM)-based chemical risk assessments. In this case study we evaluated a NAM for hepatotoxicity based on rat primary hepatocytes, high-content imaging (HCI) and in vitro to in vivo extrapolation (IVIVE). \n\nThis dataset is associated with the following publication:\nShah, I., T. Antonijevic, B. Chambers, J. Harrill, and R. Thomas. Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes.   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  183(2): 285-301, (2021).", "distribution": [{"accessURL": "https://github.com/i-shah/heprn-hci-nam", "title": "https://github.com/i-shah/heprn-hci-nam"}], "identifier": "https://doi.org/10.23719/1520925", "keyword": ["hepatotoxicity", "high-content imaging", "new approach methodologies", "pbtk", "point of departure", "repeat dose toxicity", "tipping points", "virtual embryo", "virtual liver", "virtual tissues"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2020-09-09", "programCode": ["020:095"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1093/toxsci/kfab091"], "rights": null, "title": "Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes"}