{
  "@type": "dcat:Dataset",
  "accessLevel": "public",
  "bureauCode": [
    "006:55"
  ],
  "contactPoint": {
    "fn": "Jeffrey W. Hudgens",
    "hasEmail": "mailto:jeffrey.hudgens@nist.gov"
  },
  "description": "This database gives hydrogen-deuterium exchange mass spectrometry (HDX-MS) data from measurements of three purified IgG1 glycoform samples, predominantly G0F, G2F, and SAF, in isolation and in complexation with the high-affinity receptor, Fc(gamma)RIa (CD64). The IgG1 antibody used in this study, aIL8hFc, is a murine-human chimeric IgG1, which inhibits IL-8 binding to human neutrophils. The working datasets comprise 17,750 deuterium uptake measurements in peptides from the receptor and the light and heavy chains of aIL8hFc obtained during 7 experiments, each comprising three runs of six exchange times. The data illuminate on the hydrogen exchange dynamics in isolated receptor, isolated IgG1 glycoforms, and receptor-IgG1 complexes.",
  "distribution": [
    {
      "accessURL": "https://doi.org/10.18434/mds2-2365",
      "title": "DOI Access for Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the Fc(gamma)RIa (CD64) Receptor"
    },
    {
      "description": "Glossary of post translational modifications present on peptides.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Glossary%20of%20Protein%20Modifications.pdf",
      "mediaType": "application/pdf",
      "title": "Glossary of Protein Modifications"
    },
    {
      "description": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G0F glycoform.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2314_holo-FcgR1a%28G0F%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G0F glycoform."
    },
    {
      "description": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G2F glycoform.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2315_holo-FcgR1a%28G2F%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G2F glycoform."
    },
    {
      "description": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc SAF glycoform.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2316_holo-FcgR1a%28SAF%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc SAF glycoform."
    },
    {
      "description": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%238_holo-G0F_heavy_chain%28FcgR1a%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "description": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2310_holo-G2F_heavy_chain%28FcgR1a%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "description": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2312_holo-SAF_heavy_chain%28FcgR1a%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "description": "HDX-MS data for peptides from the light chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%232_holo-G0F_light_chain%28FcgR1a%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from the light chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a ."
    },
    {
      "description": "HDX-MS data for peptides from the light chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%234_holo-G2F_light_chain%28FcgR1a%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from the light chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "description": "HDX-MS data for peptides from the light chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%236_holo-SAF_light_chain%28FcgR1a%29.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data for peptides from the light chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "description": "HDX-MS data of peptides from isolated (apo-)Fc?R1a.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2313_apo-FcgR1a.CSV",
      "format": "CSV",
      "mediaType": "application/vnd.ms-excel",
      "title": "HDX-MS data of peptides from isolated (apo-)Fc?R1a."
    },
    {
      "description": "HDX-MS data of peptides from the heavy chain of isolated (apo-)G0F IgG1 aIL8hFc.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%237_apo-G0F_heavy_chain.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data of peptides from the heavy chain of isolated (apo-)G0F IgG1 aIL8hFc."
    },
    {
      "description": "HDX-MS data of peptides from the heavy chain of isolated (apo-)G2F IgG1 aIL8hFc.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%239_apo-G2F_heavy_chain.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data of peptides from the heavy chain of isolated (apo-)G2F IgG1 aIL8hFc."
    },
    {
      "description": "HDX-MS data of peptides from the heavy chain of isolated (apo-)SAF IgG1 aIL8hFc.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2311_apo-SAF_heavy_chain.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data of peptides from the heavy chain of isolated (apo-)SAF IgG1 aIL8hFc."
    },
    {
      "description": "HDX-MS data of peptides from the light chain of isolated (apo-)G0F IgG1 aIL8hFc",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%231_apo-G0F_light_chain.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data of peptides from the light chain of isolated (apo-)G0F IgG1 aIL8hFc"
    },
    {
      "description": "HDX-MS data of peptides from the light chain of isolated (apo-)G2F IgG1 aIL8hFc",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%233_apo-G2F_light_chain.CSV",
      "format": "csv",
      "mediaType": "text/csv",
      "title": "HDX-MS data of peptides from the light chain of isolated (apo-)G2F IgG1 aIL8hFc"
    },
    {
      "description": "HDX-MS data of peptides from the light chain of isolated (apo-)G2F IgG1 aIL8hFc",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%233_apo-G2F_light_chain.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File HDX-MS data of peptides from the light chain of isolated (apo-)G2F IgG1 aIL8hFc"
    },
    {
      "description": "HDX-MS data of peptides from the light chain of isolated (apo-)SAF IgG1 aIL8hFc",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%235_apo-SAF_light_chain.CSV",
      "format": "CSV",
      "mediaType": "text/csv",
      "title": "HDX-MS data of peptides from the light chain of isolated (apo-)SAF IgG1 aIL8hFc"
    },
    {
      "description": "SHA256 File for HDX-MS data for peptides from the light chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a.",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%236_holo-SAF_light_chain%28FcgR1a%29.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data for peptides from the light chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "description": "Sequences of aILhFc and soluble FcgR1a (CD64a)",
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Sequences%20of%20aILhFc%20and%20soluble%20FcgR1a%20%28CD64a%29.pdf",
      "mediaType": "application/pdf",
      "title": "Sequences of aILhFc and soluble FcgR1a (CD64a)"
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2310_holo-G2F_heavy_chain%28FcgR1a%29.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2311_apo-SAF_heavy_chain.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data of peptides from the heavy chain of isolated (apo-)SAF IgG1 aIL8hFc."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2312_holo-SAF_heavy_chain%28FcgR1a%29.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data for peptides from the heavy chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2313_apo-FcgR1a.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data of peptides from isolated (apo-)Fc(gamma)R1a."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2314_holo-FcgR1a%28G0F%29.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G0F glycoform."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2315_holo-FcgR1a%28G2F%29.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G2F glycoform."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%2316_holo-FcgR1a%28SAF%29.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc SAF glycoform."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%231_apo-G0F_light_chain.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data of peptides from the light chain of isolated (apo-)G0F IgG1 aIL8hFc"
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%232_holo-G0F_light_chain%28FcgR1a%29.CSV.sha256",
      "mediaType": "text/csv",
      "title": "SHA256 File for HDX-MS data for peptides from the light chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a ."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%234_holo-G2F_light_chain%28FcgR1a%29.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data for peptides from the light chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%235_apo-SAF_light_chain.CSV.sha256",
      "format": "CSV",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data of peptides from the light chain of isolated (apo-)SAF IgG1 aIL8hFc"
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%237_apo-G0F_heavy_chain.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data of peptides from the heavy chain of isolated (apo-)G0F IgG1 aIL8hFc."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%238_holo-G0F_heavy_chain%28FcgR1a%29.CSV.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Dataset%239_apo-G2F_heavy_chain.CSV.sha256",
      "format": "CSV",
      "mediaType": "text/plain",
      "title": "SHA256 File for HDX-MS data of peptides from the heavy chain of isolated (apo-)G2F IgG1 aIL8hFc."
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Glossary%20of%20Protein%20Modifications.pdf.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for Glossary of Protein Modifications"
    },
    {
      "downloadURL": "https://data.nist.gov/od/ds/mds2-2365/Sequences%20of%20aILhFc%20and%20soluble%20FcgR1a%20%28CD64a%29.pdf.sha256",
      "mediaType": "text/plain",
      "title": "SHA256 File for Sequences of aILhFc and soluble FcgR1a (CD64a)"
    }
  ],
  "identifier": "ark:/88434/mds2-2365",
  "issued": "2021-06-03",
  "keyword": [
    "HDX-MS",
    "antibody-receptor interaction",
    "chromatography",
    "glycosylation",
    "hydrogen-deuterium exchange",
    "mass spectrometry",
    "monoclonal antibody",
    "peptide",
    "precision",
    "protein",
    "proteolysis",
    "proteomics",
    "receptor."
  ],
  "language": [
    "en"
  ],
  "license": "https://www.nist.gov/open/license",
  "modified": "2021-02-17 00:00:00",
  "programCode": [
    "006:045"
  ],
  "publisher": {
    "@type": "org:Organization",
    "name": "National Institute of Standards and Technology"
  },
  "theme": [
    "Bioscience:Biomaterials",
    "Bioscience:Proteomics",
    "Chemistry:Analytical chemistry",
    "Chemistry:Molecular characterization",
    "Health:Pharmaceuticals",
    "Manufacturing:Biomanufacturing",
    "Materials:Materials characterization"
  ],
  "title": "Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the Fc(gamma)RIa (CD64) Receptor"
}