{
  "accessLevel": "public",
  "bureauCode": [
    "020:00"
  ],
  "contactPoint": {
    "fn": "Leon Gray",
    "hasEmail": "mailto:gray.earl@epa.gov"
  },
  "description": "METADATA\t\t\t\t\n\t\t\t\t\nOUTLINE\t\t\t\t\n\t\t\t\t\nSHEET 1\t\t\tSTUDY INFORMATION\t\n\t\t\t\t\nSHEET 2\t\t\tRANDOM ASSISNMENT OF PREGNANT RATS TO TREATMENT GROUPS\t\n\t\t\t\t\nSHEER 3\t\t\tMATERNAL WEIGHT AND WEIGHT GAIN DURING DOSING and fetal DATA\t\n\t\t\t\tRAW DATA\n\t\t\t\tRESULTS\n\t\t\t\tPREDICTIONS OF DOSE ADDITIVITY\n\t\t\t\t\nSHEET 4\t\t\tTESTOSTERONE (T PROD) DATA\t\n\t\t\t\tRAW DATA\n\t\t\t\tSAS INPUT FILES\n\t\t\t\tTREATMENT EFFECTS\n\t\t\t\t\nSHEET 5\t\t\tCUSTOM GENE (mRNA) SAS INPUT FILE WITH SAS STATEMENTS AND RQW DATA\t\n\t\t\t\t\nSHEET 6\t\t\tRESULTS FROM STATISTICAL ANALYSIS OF CUSTOM ARRAY mRNA DATA\t\n\t\t\tCUSTOM ARRAY: LIST OF GENES AND GENE DESCRIPTIONS\t\n\t\t\t\t\nSHEET 7\t\t\tPREDICTION MODELS OF TESTOSTERONE PRODUCTION REDUCTIONS AND REPRODUCTIVE EFFECTS OF IN UTERO PHTHALATE EXPOSURE\t\n\t\t\t\t\nSHEET 8\t\t\tTREATMENT EFFECTS PREDICTED FROM THE TESTOSTERONE PREDICTION MODELS\t\n\t\t\tCOMPARISON OF THE PREDICTED EFFECTS OF THE DBP+DINP MIXTURE WITH OBSERVED EFFECTS OF THE REFERENCE CHEMICAL (DBP) AT EQUIVALENT DOSES, ASSUMING DOSE ADDITIVITY. \n\nThis dataset is associated with the following publication:\nGray, L., C. Lambright, N. Evans, J. Ford, and J. Conley. Using Targeted Fetal Rat Testis Genomic and Endocrine Alterations to Predict the Effects of a Phthalate Mixture on the Male Reproductive Tract..   Current Research in Toxicology. Elsevier B.V., Amsterdam,  NETHERLANDS, 7: 100180, (2024).",
  "distribution": [
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1530554/DBP%20DINP%20MIX%20paper%20METADATA%20FOR%20PUBLICATION.xls",
      "mediaType": "application/vnd.ms-excel",
      "title": "DBP DINP MIX paper METADATA FOR PUBLICATION.xls"
    }
  ],
  "identifier": "https://doi.org/10.23719/1530554",
  "keyword": [
    "Risk Assessment"
  ],
  "license": "https://pasteur.epa.gov/license/sciencehub-license.html",
  "modified": "2024-03-27",
  "programCode": [
    "020:000"
  ],
  "publisher": {
    "name": "U.S. EPA Office of Research and Development (ORD)",
    "subOrganizationOf": {
      "name": "U.S. Environmental Protection Agency",
      "subOrganizationOf": {
        "name": "U.S. Government"
      }
    }
  },
  "references": [
    "https://doi.org/10.1016/j.crtox.2024.100180",
    "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239482"
  ],
  "rights": null,
  "title": "Using Targeted Fetal Rat Testis Genomic and Endocrine Alterations to Predict the Effects of a Phthalate Mixture on the Male Reproductive Tract."
}