{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Michael Hornung", "hasEmail": "mailto:hornung.michael@epa.gov"}, "description": "Data set includes optimized assay parameters and kinetic characterization for xenopus laevis deiodinase type 3 enzyme, and inhibition activity of 352 ToxCast chemicals against this enzyme. \n\nThis dataset is associated with the following publication:\nMayasich, S., J. Korte, J. Denny, P. Hartig, J. Olker, P. Degoey, J. O'Flanagan, S. Degitz, and M. Hornung. Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals.   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  73: 105141, (2021).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504033/200714_Mayasich_et_al_Xldio3%20screening%20data.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "200714_Mayasich_et_al_Xldio3 screening data.xlsx"}], "identifier": "https://doi.org/10.23719/1504033", "keyword": ["Enzyme activity", "Xenopus", "deiodinase", "thyroid"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2019-06-19", "programCode": ["020:095"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1016/j.tiv.2021.105141"], "rights": null, "title": "Xenpous leavis deiodinase type 3 enzyme activity characterization and chemical screening data"}