{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Katherine Rentschler", "hasEmail": "mailto:rentschler.katherine@epa.gov"}, "description": "Dorsal third ventricle infusions of the alpha 2 adrenergic receptor antagonist, mianserin- which increases brain concentrations of dopamine, serotonin, and acetylcholine, or the glucocorticoid receptor antagonist, mifepristone, were performed in male WKY rats prior to acute ozone exposure at 0.8 ppm for 4 hours. This experiment was designed to target hippocampal and hypothalamic neuromodulation to determine the role of indoleamines, monoamines, and glucocorticoids in mediating the systemic and pulmonary effects to ozone exposure.", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532349/WKYICV-KR2024%20Science%20Hub%20Mianserin%20and%20Mife%20Manuscript%20Updated%206.9.25.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "WKYICV-KR2024 Science Hub Mianserin and Mife Manuscript Updated 6.9.25.xlsx"}], "identifier": "https://doi.org/10.23719/1532349", "keyword": ["Catecholamines", "Ozone", "air pollution", "glucocorticoids", "monoamines", "neuroendocrine stress axes", "pulmonary injury"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2025-06-09", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": null, "rights": null, "title": "The role of dorsal third ventricle \u03b12 adrenergic antagonism or glucocorticoid antagonism in modulating the neuroendocrine stress response to acute ozone exposure "}