{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for the complex cardiovascular diseases of heart failure and vascular smooth muscle intimal hyperplasia. Cardiac-specific adenovirus-mediated transfer of the carboxyl-terminus of the \u03b2-adrenergic receptor kinase (\u03b2ARKct), acting as a G\u03b2\u03b3-\u03b2-adrenergic receptor kinase (\u03b2ARK)1 inhibitor, improves basal and agonist-induced cardiac performance in both normal and failing rabbit hearts. In addition, \u03b2ARKct adenovirus infection of vascular smooth muscle is capable of significantly diminishing neointimal proliferation after angioplasty. Therefore, further investigation is warranted to determine whether inhibition of \u03b2ARK1 activity and sequestration of G\u03b2\u03b3 via an adenovirus that encodes the \u03b2ARKct transgene might be a useful clinical tool for the treatment of cardiovascular pathologies.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59618/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/32jn-t84u", "issued": "2025-07-14", "keyword": ["adrenergic-receptors", "gene-therapy", "heart-failure", "intimal-hyperplasia", "nih"], "landingPage": "https://healthdata.gov/d/32jn-t84u", "modified": "2025-09-06", "programCode": ["009:037"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Beta-Adrenergic gene therapy for cardiovascular disease"}