{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Cellular senescence is a defining property of euploid cells in\nculture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species exhibit a finite number of population doublings before undergoing an irreversible arrest of cell replication. Several genes have been implicated as effectors of senescence in culture. These include genetic components of the Rb and p53 growth regulation pathways [3,4,5,6,7,8] and genes encoding components of telomerase [9,10,11]. The p53\nand Rb pathways appear to effect senescence proper, being\nrequired for the initial cessation of growth by primary cell\ncultures [3,8,12,13,14]. In contrast, the ability of telomerase to extend culture life span is limited to cells that have first escaped senescence [8,12,13,14].", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79675/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/wtbn-ecdj", "issued": "2025-07-14", "keyword": ["asymmetric-cell-division", "cellular-senescence", "nih", "p53-protein", "stem-cell-kinetics"], "landingPage": "https://healthdata.gov/d/wtbn-ecdj", "modified": "2025-09-29", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Cellular senescence:ex vivop53-dependent asymmetric cell kinetics"}