{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "An advanced understanding of acid\u2013base physiology is as central to\t\t\t the practice of critical care medicine, as are an understanding of cardiac and\t\t\t pulmonary physiology. Intensivists spend much of their time managing problems\t\t\t related to fluids, electrolytes, and blood pH. Recent advances in the\t\t\t understanding of acid\u2013base physiology have occurred as the result of the\t\t\t application of basic physical-chemical principles of aqueous solutions to blood\t\t\t plasma. This analysis has revealed three independent variables that regulate pH\t\t\t in blood plasma. These variables are carbon dioxide, relative electrolyte\t\t\t concentrations, and total weak acid concentrations. All changes in blood pH, in\t\t\t health and in disease, occur through changes in these three variables. Clinical\t\t\t implications for these findings are also discussed.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137247/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/iv2t-3sey", "issued": "2025-07-14", "keyword": ["acid-base-balance", "acidosis-alkalosis", "blood-ph", "electrolyte-concentrations", "nih"], "landingPage": "https://healthdata.gov/d/iv2t-3sey", "modified": "2025-09-06", "programCode": ["009:037"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Determinants of blood pH in health and disease"}