{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Logan Everett", "hasEmail": "mailto:everett.logan@epa.gov"}, "description": "Dataset for Jesse Rogers et al., 'Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening' published in Environmental Health Perspectives, Vol 133, Issue 6, 067013, June 2025. DOI: https://doi.org/10.1289/EHP16024, PMC12165737\n\nR scripts for reproducing all analyses are available on Github (https://github.com/USEPA/CompTox-HTTr-RCAS). All sequencing data are available via the Gene Expression Omnibus repository (accessionnumbers GSE274318 for U-2 OS and GSE284321 for HepaRG). High-throughput screening assay data are available from InvitroDB via download 29 or the USEPA CompTox Chemicals Dashboard(https://comptox.epa.gov/dashboard/). \n\nThis dataset is associated with the following publication:\nRogers, J., J. Bundy, J. Harrill, R. Judson, K. Friedman, and L. Everett. Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening.   ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 133(6): 067013, (2025).", "distribution": [{"accessURL": "https://github.com/USEPA/CompTox-HTTr-RCAS", "title": "https://github.com/USEPA/CompTox-HTTr-RCAS"}, {"accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274318", "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274318"}, {"accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284321", "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284321"}], "identifier": "https://doi.org/10.23719/1532377", "keyword": ["Hazard Assessment", "chemical prioritization", "high-throughput transcriptomics", "new approach methodologies"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2025-03-25", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1289/ehp16024", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165737"], "rights": null, "title": "Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening"}