{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Tony McDonald", "hasEmail": "mailto:mcdonald.tony@epa.gov"}, "description": "The endpoints selected for evaluation of the HIINT formula were percent relative liver weight of mice (PcLiv) and the logarithm of ALT [Log(ALT)], where the log transformation was used to help stabilize the increases in variance with dose found in the ALT dataset.", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531675/Appendix%20A-9_Interact-HI-THMs_2021-01-31.docx", "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "title": "Appendix A-9_Interact-HI-THMs_2021-01-31.docx"}], "identifier": "https://doi.org/10.23719/1531675", "keyword": ["Binary Interaction Weight-of-Evidence", "Dose Additivity", "Hazard Index", "Mixture Effective Dose Estimation", "chemical Mixtures Risk Assessment", "chemical mixtures", "dose addition", "interactions"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2024-04-23", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": null, "rights": null, "title": "Report on Evaluation of the Interaction-based Hazard Index Formula with Data on Trihalomethanes"}