{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Richard Judson", "hasEmail": "mailto:judson.richard@epa.gov"}, "description": "The objectives of this work were to: 1) develop an integrated analysis of chemical-mediated effects on steroidogenesis in the HT-H295R assay; and, 2) evaluate whether the HT-H295R assay predicts estrogen and androgen production specifically via comparison with the OECD-validated H295R assay. \n\nThis dataset is associated with the following publication:\nHaggard, D., A. Karmaus, M. Martin, R. Judson, W. Setzer, and K. Paul-Friedman. (Toxicological Sciences) High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis.   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  162(2): 509-534, (2018).", "distribution": [{"accessURL": "https://gaftp.epa.gov/COMPTOX/NCCT_Publication_Data/Haggard/2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation/", "title": "https://gaftp.epa.gov/COMPTOX/NCCT_Publication_Data/Haggard/2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation/"}, {"accessURL": "https://github.com/USEPA/CompTox-ToxCast-EDSPsteroidogenesis", "title": "https://github.com/USEPA/CompTox-ToxCast-EDSPsteroidogenesis"}], "identifier": "https://doi.org/10.23719/1407003", "keyword": ["ACToR", "EDSP21", "ToxCast", "steroidogenesi"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2017-09-08", "programCode": ["020:095"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1093/toxsci/kfx274"], "rights": null, "title": "2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation"}