{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH/NCBI Data Team", "hasEmail": "mailto:info@ncbi.nlm.nih.gov"}, "description": "Disclosed herein are tetrahydro-benzo [e] isoindolines useful in the treatment of hypertension, which are represented by the formula <CHEM> wherein R, R1, and R2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, benzyloxy, benzoyloxy, thiomethyl, halo, or <CHEM> wherein R4 and R5 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula <CHEM> wherein R6 is loweralkyl of 1 to 4 carbon atoms; or R and R1, or R1 and R2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R1 or R2 must be other than hydrogen; and R3 is hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula <CHEM> wherein m is 0, 1 or 2, p is 0 or 1, R7 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R8 and R9 are independently selected from hydrogen, hydroxy, methoxy, loweralkyl of 1 to 4 carbon atoms, or halo, or R8 and R9 can be taken together to form a methylendioxy or ethylenedioxy bridge; or 1,4-benzodioxan.", "distribution": [{"@type": "dcat:Distribution", "description": "Access the complete Patent AT-E40115-T1: [Translated] TETRAHYDRO-BENZO (E) ISOINDOLINE. on the official website.", "downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E40115-T1", "mediaType": "text/html", "title": "Official Data Source"}], "identifier": "https://healthdata.gov/api/views/duwj-qgb5", "issued": "2025-09-05", "keyword": ["chemistry", "innovation", "patent", "pubchem", "research"], "landingPage": "https://healthdata.gov/d/duwj-qgb5", "modified": "2025-09-06", "programCode": ["009:066"], "publisher": {"@type": "org:Organization", "name": "National Center for Biotechnology Information (NCBI)"}, "theme": ["NIH"], "title": "Patent AT-E40115-T1: [Translated] TETRAHYDRO-BENZO (E) ISOINDOLINE."}