{
  "@type": "dcat:Dataset",
  "accessLevel": "public",
  "bureauCode": [
    "009:25"
  ],
  "contactPoint": {
    "@type": "vcard:Contact",
    "fn": "NIH",
    "hasEmail": "mailto:info@nih.gov"
  },
  "description": "Background:\n          The mechanisms by which partial liquid ventilation (PLV) can\n\t\t\t\timprove gas exchange in acute lung injury are still unclear. Therefore, we\n\t\t\t\texamined the time- and dose-dependency of the improvements in arterial oxygen\n\t\t\t\ttension (PaO2) due to PLV in eight pigs with experimental lung\n\t\t\t\tinjury, in order to discriminate increases due to oxygen dissolved in\n\t\t\t\tperfluorocarbon before its intrapulmonary instillation from a persistent\n\t\t\t\tdiffusion of the respiratory gas through the liquid column.\n        \n        \n          Results:\n          Application of four sequential doses of perfluorocarbon resulted\n\t\t\t\tin a dose-dependent increase in PaO2. Comparison of measurements 5\n\t\t\t\tand 30 min after instillation of each dose revealed a time-dependent decrease in\n\t\t\t\tPaO2 for doses that approximated the functional residual capacity of\n\t\t\t\tthe animals.\n        \n        \n          Conclusion:\n          Although oxygen dissolved in perfluorocarbon at the onset of PLV\n\t\t\t\tcan cause a short-term improvement in arterial oxygenation, diffusion of oxygen\n\t\t\t\tthrough the liquid may not be sufficient to maintain the initially observed\n\t\t\t\tincrease in PaO2.",
  "distribution": [
    {
      "@type": "dcat:Distribution",
      "description": "Visit the original government dataset for complete information, documentation, and data access.",
      "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29038/",
      "mediaType": "text/html",
      "title": "Official Government Data Source"
    }
  ],
  "identifier": "https://healthdata.gov/api/views/xg8f-h2cx",
  "issued": "2025-07-13",
  "keyword": [
    "ards",
    "liquid-ventilation",
    "nih",
    "oxygenation",
    "perfluorocarbon"
  ],
  "landingPage": "https://healthdata.gov/d/xg8f-h2cx",
  "modified": "2025-09-06",
  "programCode": [
    "009:048"
  ],
  "publisher": {
    "@type": "org:Organization",
    "name": "National Institutes of Health"
  },
  "theme": [
    "NIH"
  ],
  "title": "Time-dependency of improvements in arterial oxygenation during partial\n\t\t  liquid ventilation in experimental acute respiratory distress syndrome"
}