{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Tumor necrosis factor-\u03b1 (TNF-\u03b1) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-\u03b1 on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-\u03b1 disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-\u03baB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-\u03b1 effects on skeletal muscle and the mechanism of TNF-\u03b1 action.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59514/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/p5c4-ivk4", "issued": "2025-07-14", "keyword": ["muscle-wasting", "nih", "skeletal-muscle", "tnf-alpha"], "landingPage": "https://healthdata.gov/d/p5c4-ivk4", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Tumor necrosis factor-\u03b1 and muscle wasting: a cellular perspective"}