{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Glucocorticoids (GCs) are routinely used as anti-inflammatory drugs in the treatment of asthma. They act through binding to glucocorticoid receptor \u03b1 (GR\u03b1), which represses numerous genes encoding pro-inflammatory mediators. A hormone binding deficient GR isoform named GR\u03b2 has been isolated in humans. When overexpressed by transfection, GR\u03b2 may function as a dominant negative modulator of GR\u03b1. However, to act as such, GR\u03b2 has to be more abundant than GR\u03b1, and conflicting data have been obtained concerning the relative levels of the two isoforms in cell lines and freshly isolated cells. Moreover, the dominant negative effect was not confirmed by independent laboratories. In GC-resistant asthmatics, GR\u03b2 was expressed by an increased number of peripheral blood mononuclear cells (PBMCs), airway T cells, and cells found in skin biopsies of tuberculin responses. However, the relative amounts of GR\u03b1 and GR\u03b2 in these cells were not determined. In GC-dependent asthmatics, PBMCs expressed GR\u03b1 predominantly. No cells containing higher levels of GR\u03b2 than GR\u03b1 have yet been reported in asthmatics. Even if the existence of such cells is demonstrated, the role of GR\u03b2 in asthma will remain a matter of controversy because functional studies have given discrepant data.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59562/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/w9v6-wz25", "issued": "2025-07-14", "keyword": ["anti-inflammatory-drugs", "asthma-glucocorticoids", "glucocorticoid-receptor", "nih", "steroid-resistance"], "landingPage": "https://healthdata.gov/d/w9v6-wz25", "modified": "2025-09-06", "programCode": ["009:048"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Is there a role for glucocorticoid receptor beta in asthma?"}