{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background:\n          In order to test the hypothesis that inhaled nitric oxide (NO) reverses the pulmonary hypertension induced by \u03b1\u03b1-diaspirin crosslinked hemoglobin (\u03b1\u03b1Hb), were studied anesthetized pigs that were administered with a total dose of 200 mg/kg of 10% \u03b1\u03b1Hb. Inhaled NO (5 ppm) was administered for 10 min, and then discontinued for 10 min. This cycle was then repeated with 10 ppm inhaled NO.\n        \n        \n          Results:\n          \u03b1\u03b1Hb caused pulmonary arterial pressure (PAP) to increase from 27 \u00b1 1.7 to 40 \u00b1 3.0 mmHg (P<0.05) and dynamic lung compliance to decrease from 29\u00b1 1.5 to 23\u00b1 1.6 ml/cmH2O (P < 0.05). After both doses of inhaled NO, but particularly 10 ppm, PAP was reduced (P < 0.05) and lung compliance increased (P < 0.05) from the \u03b1\u03b1Hb levels. When inhaled NO was discontinued PAP again increased and lung compliance decreased to levels significantly different from baseline (P < 0.05).\n        \n        \n          Conclusion:\n          We conclude that cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance can be selectively counteracted by inhaled NO.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC28996/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/k4qy-2tvr", "issued": "2025-07-13", "keyword": ["cell-free-hemoglobin", "inhaled-nitric-oxide", "lung-compliance", "nih", "pulmonary-hypertension"], "landingPage": "https://healthdata.gov/d/k4qy-2tvr", "modified": "2025-09-06", "programCode": ["009:037"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary results"}