{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Destruction of cartilage and bone are hallmarks of human rheumatoid\n\t\t\t arthritis (RA), and controlling these erosive processes is the most challenging\n\t\t\t objective in the treatment of RA. Systemic interleukin-4 treatment of\n\t\t\t established murine collagen-induced arthritis suppressed disease activity and\n\t\t\t protected against cartilage and bone destruction. Reduced cartilage pathology\n\t\t\t was confirmed by both decreased serum cartilage oligomeric matrix protein\n\t\t\t (COMP) and histological examination. In addition, radiological analysis\n\t\t\t revealed that bone destruction was also partially prevented. Improved\n\t\t\t suppression of joint swelling was achieved when interleukin-4 treatment was\n\t\t\t combined with low-dose prednisolone treatment. Interestingly, synergistic\n\t\t\t reduction of both serum COMP and inflammatory parameters was noted when\n\t\t\t low-dose interleukin-4 was combined with prednisolone. Systemic treatment with\n\t\t\t interleukin-4 appeared to be a protective therapy for cartilage and bone in\n\t\t\t arthritis, and in combination with prednisolone at low dosages may offer an\n\t\t\t alternative therapy in RA.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17779/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/i6dc-j657", "issued": "2025-07-13", "keyword": ["bone-destruction", "cartilage-protection", "collagen-induced-arthritis", "interleukin-4-treatment", "nih"], "landingPage": "https://healthdata.gov/d/i6dc-j657", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Protection against cartilage and bone destruction by systemic\n\t\t  interleukin-4 treatment in established murine type II collagen-induced\n\t\t  arthritis"}