{
  "accessLevel": "public",
  "bureauCode": [
    "020:00"
  ],
  "contactPoint": {
    "fn": "Sheau-Fung Thai",
    "hasEmail": "mailto:thai.sheau-fung@epa.gov"
  },
  "description": "Signaling pathways  from IPA:  canonical pathways obtained by uploading differentially expressed genes onto IPA to get the corresponding pathways altered by the chemicals.\n\nFigure 4 ABCDHILM ROS final:  Excel file with raw data and calculated fold change for the ROS (Deep Red) assay on 8 nanoparticles.\n\nData files for tables:  this file include physical-chemical properties of the 8 NPs (worksheet 1), sizing and zeta potential from zeta sizer (worksheet 2&3) and numbers of differentially expressed genes (DEGs) (worksheet 4).\n\nData files for figure 5 to 11:  physical -chemical properties of the NPs, raw data and calculation for ROS-RNS, 8-oxo-dG, AP sites, endogenous DNA adducts, 4-HNE, and MDA adducts. \n\nThis dataset is associated with the following publication:\nThai, S., C. Jones, G. Nelson, B. Vallanat, M. Killius, J. Crooks, w. Ward, C. Blackman, and J. Ross. Differential effects of Nano TiO2 and CeO2 on normal human lung epithelial cells in vitro.   Journal of Nanoscience and Nanotechnology. American Scientific Publishers, VALENCIA, CA, USA, 19(11): 6907-6923, (2019).",
  "distribution": [
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502468/Copy%20of%20figur%204%20Nano%20ABCDHILM%20ROS%20final.xlsx",
      "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
      "title": "Copy of figur 4 Nano ABCDHILM ROS final.xlsx"
    },
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502468/Copy%20of%20signaling%20pathways%20from%20IPA.xlsx",
      "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
      "title": "Copy of signaling pathways from IPA.xlsx"
    },
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502468/Figure%201-3.docx",
      "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
      "title": "Figure 1-3.docx"
    },
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502468/copy%20of%20table%20for%207%20nano%20on%20BEAS2B%205-9-18.xlsx",
      "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
      "title": "copy of table for 7 nano on BEAS2B 5-9-18.xlsx"
    },
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502468/data%20files%20for%20figures.xlsx",
      "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
      "title": "data files for figures.xlsx"
    }
  ],
  "identifier": "https://doi.org/10.23719/1502468",
  "keyword": [
    "DNA damage assays",
    "Reactive oxygen species",
    "engineered nanomaterials",
    "signaling pathways analysis",
    "transcriptomics"
  ],
  "license": "https://pasteur.epa.gov/license/sciencehub-license.html",
  "modified": "2018-07-09",
  "programCode": [
    "020:095"
  ],
  "publisher": {
    "name": "U.S. EPA Office of Research and Development (ORD)",
    "subOrganizationOf": {
      "name": "U.S. Environmental Protection Agency",
      "subOrganizationOf": {
        "name": "U.S. Government"
      }
    }
  },
  "references": [
    "https://doi.org/10.1166/jnn.2019.16737"
  ],
  "rights": null,
  "title": "data sets for Nano TiO2 & CeO2 effects on BEAS-2B cells"
}