{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background and Purpose\n          The impact of traumatic brain injury (TBI) on the pathogenesis of Alzheimer disease (AD) is still controversial. The aim of our retrospective autopsy study was to assess the impact of TBE and ApoE allele frequency on the development of AD.\n        \n        \n          Material and Methods\n          We examined 1. the incidence of AD pathology (Braak stageing, CERAD, NIA-Reagan Institute criteria) in 58 consecutive patients (mean age \u00b1 SD 77.0 \u00b1 6.8 years) with residual closed TBI lesions, and 2. the frequency of TBI residuals in 57 age-matched autopsy proven AD cases. In both series, ApoE was evaluated from archival paraffin-embedded brain material.\n        \n        \n          Results\n          1. TBE series: 12.1 % showed definite and 10.3% probable AD (mean age 77.6 and 75.2 years), only 2/13 with ApoE\u03b53/4. From 45 (77.6%) non-AD cases (mean age 78.2 years), 3 had ApoE\u03b53/4. The prevalence of 22.4% AD in this small autopsy cohort was significantly higher than 3.3% in a recent large clinical series and 14% in the general population over age 70. 2. In the AD cohort with ApoE\u03b54 allele frequency of 30% similar to other AD series, residuals of closed TBI were seen in 4 brains (7%) (mean age \u00b1 SD 78.2 \u00b1 6.4), all lacking the ApoE\u03b54 allele. TBI incidence was slightly lower than 8.5% in the clinical MIRAGE study.\n        \n        \n          Conclusions\n          The results of this first retrospective autopsy study of TBI, ApoE\u03b5 allele frequency, and AD confirm clinical studies suggesting severe TBI to be a risk factor for the development AD higher in subjects lacking ApoE\u03b54 alleles. Further studies in larger autopsy series are needed to elucidate the relationship between TBI, genetic predisposition, and AD.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC37390/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/ekjs-rmud", "issued": "2025-07-14", "keyword": ["alzheimer-disease", "apoe-genotype", "autopsy-study", "nih", "traumatic-brain-injury"], "landingPage": "https://healthdata.gov/d/ekjs-rmud", "modified": "2025-09-06", "programCode": ["009:034"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype"}